Results 211 to 220 of about 623,412 (262)

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3387-3396, October 2026.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors. [PDF]

Nat Chem Biol
Algov I, Van Heest A, Hopton M, Liang F, Holmes A, Hao L, Zhou X.   +6 more
europepmc   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3598-3610, October 2026.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer. [PDF]

J Cereb Blood Flow Metab
Kim SJ, Ibrahimy A, Constantinescu CC, Hoye J, Searle GE, Slifstein M, Rabiner EA, Morris ED.   +7 more
europepmc   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Synergistic effects of action observation and object affordance on cortical excitability during BCI-triggered motor imagery in stroke: a randomized, within-subject, 2 × 2 factorial study protocol. [PDF]

Front Hum Neurosci
Su Y, Yan X, Li W, Wang Y, Wu X.
europepmc   +1 more source

Zinc is a key regulator of the sperm-specific K⁺ channel (Slo3) function. [PDF]

Elife
Andriani RT, Pipatpolkai T, Miyata H, Ikawa M, Okamura Y, Kawai T.   +5 more
europepmc   +1 more source

Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome. [PDF]

J Cell Biol
Schaeffer A, Buracco S, Gazzola M, Gelin M, Vianay B, de Pascalis C, Blanchoin L, Théry M.   +7 more
europepmc   +1 more source

Multiplexed Fiber-Optic Fluorescence for Functional Monitoring of Perfused Hearts. [PDF]

Anal Chem
Qiu J, Waters E, Lupton E, Baark F, Wallabregue ALD, Conway SJ, Southworth R, Bergholt MS.   +7 more
europepmc   +1 more source

Preclinical evaluation of [¹⁸F]fluoroethylresorufin as PET tracer for cerebral amyloid angiopathy. [PDF]

EJNMMI Res
Bleher D, Poxleitner M, Grotegerd AK, Hihn O, Kuebler L, Bowden G, Schaller M, Maier FC, Weigelin B, Pichler BJ, Maurer A, Herfert K.   +11 more
europepmc   +1 more source