Results 51 to 60 of about 12,766,596 (284)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Optimization of urban resources efficiency in the domain of water–energy–food nexus through integrated modeling: a case study of Addis Ababa city

Water Policy, 2022
This study aims to understand the long-term (2020–2050) urban water–energy–food (WEF) resources access and sustainability in Addis Ababa city through a nexus modeling approach.
Bedassa Dessalegn Kitessa, Semu Moges Ayalew, Geremew Sahilu Gebrie, Solomon T/mariam Teferi   +3 more
doaj   +1 more source

Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice [PDF]

, 2009
In order to assess nutritional adequacy, valid estimates of nutrient intake are required. One of the main errors in dietary assessment is misreporting. The objective was to review the extent, nature and determinants of misreporting in dietary assessment,
Posluna, K., Jakubikova, M., Vries, J.H.M., de, Ruprich, J., Veer, P., van 't, van 't Veer, P., de Vries, J.H.M.   +6 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Bridging complexity: surrogate modeling of soil organic carbon interannual stock changes across the key agricultural regions of Australia

Carbon Management
Understanding the key drivers of soil organic carbon (SOC) stock changes (ΔSOC) is essential for accurately modelling national greenhouse gas (GHG) inventories and carbon accounting projects.
Senani Karunaratne, Chiara Pasut, Nick Shepherd, Dan Zwartz, Sabastine Ugbaje, Dan Pagendam   +5 more
doaj   +1 more source

Towards Blockchain-Based Energy Trading: A Smart Contract Implementation of Energy Double Auction and Spinning Reserve Trading

Energies, 2022
The decentralization of power generation driven by the rise in the adoption of distributed energy resources paves the way for a new paradigm in grid operations. P2P energy trading is beneficial to the grid as well as the connected peers.
Uyikumhe Damisa, Nnamdi I. Nwulu, Pierluigi Siano   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Optimisation framework of biomass supply chain in southwest Nigeria

Cleaner Engineering and Technology
The article investigates the development of a biomass supply chain model by studying the logistic, network optimisation, transportation and economic impact as it affects the southwest Nigeria, with a particular emphasis on the conversion of crop residues
Olukolade F. Ogunrewo, Nnamdi I. Nwulu
doaj   +1 more source