Results 91 to 100 of about 1,526,476 (315)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Efficiency and equity considerations in pricing and allocating irrigation water [PDF]
Economic efficiency has to do with how much wealth a given resource base can generate. Equity has to do with how that wealth is to be distributed in society. Economic efficiency gets far more attention, in part because equity considerations involve value
Tsur, Yacov, Dinar, Ariel
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Water-use, growth and water-use efficiency of indigenous tree species in a range of forest and woodland systems in South Africa [PDF]
, 2011 This study was initiated to explore whether indigenous tree species use less water than introduced plantation tree species, whether they use that water more efficiently in terms of biomass accumulation, and consequently whether there is scope for the ...
Gush, Mark Baudert
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Optimizing Crop Spatial Structure to Improve Water Use Efficiency and Ecological Sustainability in Inland River Basin [PDF]
Inland arid basins face the challenge of ecological deterioration due to insufficient water availability. The irrigation water consumption depletes the water flowing into the downstream tailrace ecological wetland, leading to increasing ecological ...
Zihan Wu +4 more
core +1 more source
Biofuel, land and water: maize, switchgrass or Miscanthus?
Environmental Research Letters, 2013 The productive cellulosic crops switchgrass and Miscanthus are considered as viable biofuel sources. To meet the 2022 national biofuel target mandate, actions must be taken, e.g., maize cultivation must be intensified and expanded, and other biofuel ...
Qianlai Zhuang, Zhangcai Qin, Min Chen
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Irrigation water use efficiency in collective irrigated schemes of Tunisia: determinants and potential irrigation cost reduction [PDF]
This study aims first to measure the farm specific irrigation water use efficiency (IWUE), through non parametric DEA model; and second to evaluate the potential irrigation cost reductions and identify the main factors causing variations in IWUE among ...
Frija, Aymen +2 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Water in the 2010 Virginia General Assembly [PDF]
, 2010 The 2010 Virginia General Assembly convened January 13 and adjourned March 13. The reconvened (“veto”) session was held April 21. During the session, the Assembly considered 2964 measures, passing 1598 of them, defeating 1093, and continuing 273 until ...
Virginia Water Resources Research Center
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