Results 81 to 90 of about 13,840,677 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Penerapan Metode Six Sigma Pada Pengendalian Kualitas Air Baku Pada Produksi Makanan

open access: yesJurnal Ilmiah Teknik Industri, 2017
The quality of water as a raw material in the process of food production has an important role. Water quality control is the key in maintaining production.
Dino Rimantho, Desak Made Mariani
doaj   +1 more source

Reducing soil degradation to increase resilience to climate change and strengthen livelihoods in Ethiopia. [PDF]

open access: yes, 2019
Soil degradation is a major problem in Ethiopia. Depletion of soil organic matter is a cause of low agricultural productivity, as soils become less fertile and less resilient to extreme weather events, which are expected to increase with climate change ...
International Water Management Institute
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The consumptive water footprint of the European Union energy sector

open access: yesEnvironmental Research Letters, 2019
Energy security for the EU is a priority of the European Commission. Although both blue and green water resources are increasingly scarce, the EU currently does not explicitly account for water resource use in its energy related policies.
Davy Vanham   +4 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Satisfaction, water and fertilizer use in the American residential macrosystem

open access: yesEnvironmental Research Letters, 2016
Residential yards across the US look remarkably similar despite marked variation in climate and soil, yet the drivers of this homogenization are unknown.
Peter M Groffman   +16 more
doaj   +1 more source

Reducing poverty through integrated management of groundwater and surface water [PDF]

open access: yes
Groundwater management / Irrigation management / Domestic water / Poverty / Asia / India ...
International Water Management Institute (IWMI) / Global Water Partnership (GWP) Advisory Center
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

THE EFFECTS OF PESTICIDES IN WATER RESOURCES [PDF]

open access: yesJournal of Central European Agriculture, 2004
Environmental pollution is concerned problem all around world due to rapid increase of industrialization and urbanization. Especially, the intensive pesticide use has caused some environmental problems in many countries.
CUMHUR AYDINALP, M PORCA
doaj  

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