Results 41 to 50 of about 1,775,384 (336)

Study on softening characteristics of mudstones in shallow buried strata in Xinjiang and countermeasures for tunnel support

open access: yes矿业科学学报, 2021
The Xinjiang water conveyance tunnel is a shallow buried mudstone stratum. After the water absorption, the strength of the surrounding rock softens and large deformation occurs.
Zhang Yong   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Use spectral derivatives for estimating canopy water content [PDF]

open access: yes, 1973
Hyperspectral remote sensing has demonstrated great potential for accurate retrieval of canopy water content (CWC). This CWC is defined by the product of the leaf equivalent water thickness (EWT) and the leaf area index (LAI).
Clevers, J.G.P.W.
core   +7 more sources

Regulation of bicarbonate secretion in marine fish intestine by the calcium-sensing receptor [PDF]

open access: yes, 2018
In marine fish, high epithelial intestinal HCO3- secretion generates luminal carbonate precipitates of divalent cations that play a key role in water and ion homeostasis.
Fuentes, Juan, Gregorio, Silvia
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Durability and water absorption behaviour of rubberised concrete incorporating burnt clay brick powder

open access: yesCleaner Materials, 2022
Rubberised concrete has suffered from reduced durability and water absorption performance compared to conventional concrete and its decreased durability is limiting its practical use.
David Sinkhonde   +3 more
doaj   +1 more source

Near-Infrared Spectroscopy of the Bright Kuiper Belt Object 2000 EB173 [PDF]

open access: yes, 2000
We have obtained a near-infrared spectrum of the bright Kuiper Belt object 2000 EB173; the spectrum appears featureless. The spectrum has a sufficient signal-to-noise ratio to rule out the 1.5 and 2.0 μm absorption from water ice even at the low level ...
Blake, Geoffrey A.   +2 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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