Results 41 to 50 of about 6,464,138 (242)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

An assessment of the water absorption properties of an orange peel particulate-based epoxy composite by optimisation

open access: yesEngineering and Applied Science Research, 2017
Biocomposites are numerous and of increasing use in a wide range of composite applications in recent years. To achieve an overall low life-cycle cost, water absorption characteristics are of significant interest.
Oluwaseyi Ayodele Ajibade   +2 more
doaj   +1 more source

Water absorption of wood-polymer composites of savewood [PDF]

open access: yesE3S Web of Conferences, 2019
The materials based on wood-polymer composites (WPC) in the form of decking boards are produced, in which wood filler is partially replaced by mineral one.
Matseevich Tatyana   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The sweet life: diet sugar concentration influences paracellular glucose absorption [PDF]

open access: yes, 2008
Small birds and bats face strong selection pressure to digest food rapidly in order to reduce digesta mass carried during flight. One mechanism is rapid absorption of a high proportion of glucose via the paracellular pathway (transfer between epithelial ...
McWhorter, T.   +18 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Two-Phase Ammonia-Water Absorption in Mini-Channel Annulus [PDF]

open access: yes, 2012
In order to reduce investment costs and refrigerant charge for heat pump equipment, the design of the required heat exchangers should be optimized. Mini-channels heat exchangers are proposed since they can dissipate a higher heat flux and they can be ...
van de Bor, Dennis Marijn   +2 more
core   +1 more source

Detection of water vapour absorption around 363 nm in measured atmospheric absorption spectra and its effect on DOAS evaluations [PDF]

open access: yesAtmospheric Chemistry and Physics, 2017
Water vapour is known to absorb radiation from the microwave region to the blue part of the visible spectrum with decreasing efficiency. Ab initio approaches to model individual absorption lines of the gaseous water molecule predict absorption lines up ...
J. Lampel   +11 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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