Results 231 to 240 of about 19,321,440 (303)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

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Reducing Water Activity by Zeolite Molecular Sieve Membrane for Long‐Life Rechargeable Zinc Battery

Advanced Materials, 2021
Aqueous electrolytes offer major advantages in safe battery operation, green economy, and low production cost for advanced battery technology. However, strong water activity in aqueous electrolytes provokes a hydrogen evolution reaction and parasitic ...
Huijun Yang, , Zhi Chang
exaly   +2 more sources

Water activity, not moisture content, explains the influence of water on powder flowability

LWT - Food Science and Technology, 2019
. The effect of water content on the flow factor of pectin powder was investigated. Water content was expressed either as water activity or as moisture content.
E Juarez-Enriquez, Guadalupe I Olivas, E Ortega-Rivas   +2 more
exaly   +2 more sources

Relationship between the gas hydrate suppression temperature and water activity in the presence of thermodynamic hydrate inhibitor

, 2020
Hydrate formation and blockage in deepwater oil and gas operations can be prevented by using thermodynamic hydrate inhibitors (THIs). The presence of THIs changes the hydrate suppression temperature; therefore, predicting the change in the hydrate ...
Xin Zhao, Z. Qiu, Zhen Zhang, Yubin Zhang   +3 more
semanticscholar   +1 more source

Water activity and pseudo-activity coefficient of sorbed water

Journal of Food Engineering, 1990
Abstract The sorption isotherm can be represented by a plot of the logarithm of a pseudo-activity coefficient log f′ = loga w − log W against W, the weight of water per 100 g of dried substance. This plot demonstrates the polyphasic behaviour of the system. With reference to the curve for a w = 1, the chemical potentials Δμ Φ for the first
BRAIBANTI, Antonio, FISICARO, Emilia, Palmia, F.   +2 more
openaire   +2 more sources

Aflatoxin B1 (AFB1) production by Aspergillus flavus and Aspergillus parasiticus on ground Nyjer seeds: The effect of water activity and temperature.

Journal of food microbiology, 2019
Nyjer oil seed cake supports high levels of aflatoxin B1 (AFB1) production. AFB1 is a secondary metabolite of Aspergillus flavus and A. parasiticus, classified as a Class 1A carcinogen.
D. Gizachew, Chih-Hsuan Chang, B. Szonyi, Sandra De La Torre, W. Ting   +4 more
semanticscholar   +1 more source

Regulating Water Activity for All‐Climate Aqueous Zinc‐Ion Batteries

Advanced Energy Materials
Suppressing the water activity is challenging to achieve high‐performing aqueous zinc ion batteries (AZIBs), especially for its practical climate adaptability.
Yifan Wang, Li’e Mo, Xianxi Zhang, Yingke Ren, Tingting Wei, Yi He, Yang Huang, Hong Zhang, Peng Tan, Zhaoqian Li, Jiang Zhou, Linhua Hu   +11 more
semanticscholar   +1 more source