Results 71 to 80 of about 38,351,436 (316)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Google Earth Engine: Planetary-scale geospatial analysis for everyone

, 2017
Google Earth Engine is a cloud-based platform for planetary-scale geospatial analysis that brings Google's massive computational capabilities to bear on a variety of high-impact societal issues including deforestation, drought, disaster, disease, food ...
N. Gorelick, Matt Hancher, M. Dixon, S. Ilyushchenko, D. Thau, R. Moore   +5 more
semanticscholar   +1 more source

How to Collect your Water Sample and Interpret the Results for the Poultry Analytical Package [PDF]

, 2017
Rapidly growing birds may consume up to twice as much water as feed (Scantling and Watkins 2013), which means a plentiful supply of clean water is crucial for poultry health and productivity.
Austin, Bradley J., Daniels, Mike, Haggard, Brian E., Payne, Josh B., Watkins, Susan E.   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Room temperature silanization of Fe3O4 for the preparation of phenyl functionalized magnetic adsorbent for dispersive solid phase extraction for the extraction of phthalates in water

Green Processing and Synthesis, 2019
The preparation of magnetic solid adsorbents for solid phase extraction often involved time-consuming stepwise reaction and high-temperature reaction. In this study, the coating of silica and the functionalization of magnetite were performed in a single ...
Faraj Benrabha Abdulhadi Muftah, Tay Kheng Soo   +1 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Global evaluation of heavy metal content in surface water bodies: A meta-analysis using heavy metal pollution indices and multivariate statistical analyses.

Chemosphere, 2019
Water is polluted by increasing activities of population and the necessity to provide them with goods and services that use water as a vital resource. The contamination of water due to heavy metals (HMs) is a big concern for humankind; however, global ...
Vinod Kumar, R. D. Parihar, Anket Sharma, P. Bakshi, Gagan Preet Singh Sidhu, Aditi Shreeya Bali, I. Karaouzas, R. Bhardwaj, Ashwani Kumar Thukral, Y. Gyasi‐Agyei, J. Rodrigo‐Comino   +10 more
semanticscholar   +1 more source

Polydopamine-Coated Magnetite as a Sensing Material for the Optical Detection of Cationic Surfactants

Chemosensors
The sensing of surfactants is a topic of interest for industrial and environmental purposes. Polydopamine-coated magnetite (Fe3O4@PDA) can be a relevant support for the detection of cationic surfactants in water samples.
Alberto Fernández-Núñez, Francisco Pérez-Pla, Maria Ángeles Úbeda, Pedro Amorós, José V. Ros-Lis   +4 more
doaj   +1 more source

Direct As(V) Determination Using Screen-Printed Electrodes Modified with Silver Nanoparticles

Nanomaterials, 2020
Carbon-nanofiber-based screen-printed electrodes modified with silver nanoparticles (Ag-NP-SPCNFEs) were tested in a pioneering manner for the direct determination of As(V) at low μg L−1 levels by means of differential pulse anodic stripping voltammetry.
Karina Torres-Rivero, Clara Pérez-Ràfols, Julio Bastos-Arrieta, Antonio Florido, Vicenç Martí, Núria Serrano   +5 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source