Results 61 to 70 of about 523,256 (303)

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Integrative description of Pseudechiniscus (Meridioniscus) goldsteini sp. nov. from Madeira (Portugal)

open access: yesThe European Zoological Journal
Using integrative taxonomy, we describe a new species from Ribeira Brava, Madeira (Portugal), belonging to the genus Pseudechiniscus and subgenus Meridioniscus. The new species, Pseudechiniscus (Meridioniscus) goldsteini sp. nov.
P. Kayastha   +5 more
doaj   +1 more source

Flow–solid coupling analysis of underground reinforced concrete forked pipe enclosing rock and structure

open access: yesScientific Reports, 2023
The stability of the surrounding rock for the construction excavation and the reinforcement of the lining structure during operation in the water-rich area is a difficult problem for the design of high-head underground turnout pipes.
Ming Xiao   +3 more
doaj   +1 more source

Environmental Impacts of Mountain Biking: Science Review and Best Practices [PDF]

open access: yes, 2007
Mountain biking is still a relatively new activity whose environmental impact and contribution to trail degradation is poorly understood. As with all recreational pursuits, it is clear that mountain biking contributes some degree of environmental ...
Jeff Marion, Jeremy Wimpey
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Annual Report: 2012 [PDF]

open access: yes, 2013
I submit herewith the annual reports from the Agricultural and Forestry Experiment Station, School of Natural Resources and Agricultural Sciences, University of Alaska Fairbanks, for the period ending December 31, 2012.

core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Whiz Bangs and Whoolly Bears: Walter Estabrooks and the Great War, Compiled from His Diary and Letters [PDF]

open access: yes, 2012
The Order of Battle for the Canadian Corps during World War One included the 32nd Field Battery of the Canadian Field Artillery (CFA), in the 8th Army Brigade. One memorable gunner who served in that unit was Sergeant Walter Ray Estabrooks.
Skaarup, Hal A.
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

High contributions of sea ice derived carbon in polar bear (Ursus maritimus) tissue.

open access: yesPLoS ONE, 2018
Polar bears (Ursus maritimus) rely upon Arctic sea ice as a physical habitat. Consequently, conservation assessments of polar bears identify the ongoing reduction in sea ice to represent a significant threat to their survival.
Thomas A Brown   +5 more
doaj   +1 more source

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