Results 41 to 50 of about 1,564,338 (310)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Bioavailability and Migration Features of Metals in “Bottom Sediments – Water” System under the Action of Different Environmental Factors

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2023
This review considers and summarizes findings of the studies on metals’ coexisting forms in bottom sediments of surface water bodies. This makes it possible to assess metals’ migration ability in the “bottom sediments – water” system and their potential ...
Petro Linnik, Vladyslav Zhezherya, Rostyslav Linnik   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Statistical analysis of hydrochemical parameters of drainage and waste waters from a rice irrigation system

Мелиорация и гидротехника
Purpose: statistical analysis of hydrochemical parameters of drainage and waste water (DWW) from a rice irrigation system located in the Bagaevsky district Rostov region. Materials and methods.
Tatyana I. Drovovozova, Darya V. Milchenkova   +1 more
doaj   +1 more source

Improving the Methodological Support of Environmental Forensics

Теория и практика судебной экспертизы, 2022
The article addresses methodical support of forensic environmental research and national standards of the Russian Federation (GOSTs), which are also used for methodological purposes.The author demonstrates that in studies of the ecological condition of ...
N. V. Mikhaleva
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Water Body Extraction from Very High Spatial Resolution Remote Sensing Data Based on Fully Convolutional Networks

Remote Sensing, 2019
This paper studies the use of the Fully Convolutional Networks (FCN) model in the extraction of water bodies from Very High spatial Resolution (VHR) optical images in the case of limited training samples.
Liwei Li, Zhi Yan, Qian Shen, Gang Cheng, Lianru Gao, Bing Zhang   +5 more
doaj   +1 more source

Body condition of shorebirds upon arrival at their Siberian breeding grounds

, 2009
Arctic breeding shorebirds carry substantial body stores on their long-distance migrations from their non-breeding grounds. Upon arrival at the breeding area the remains of these stores can be used for egg formation, insurance against poor feeding ...
Klaassen, Raymond, Tulp, Ingrid, Visser, G. Henk, Klaassen, Raymond H. G., Ens, Bruno J., Ens, B.J., Tulp, I., Schekkerman, H., Visser, G.H., Schekkerman, Hans, Tulp, I.Y.M., Klaassen, R.H.G.   +11 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source