Results 51 to 60 of about 9,492,490 (285)

Monitoring African water bodies from twice-daily MODIS observation

open access: yesGIScience & Remote Sensing, 2018
Building on the availability of high revisit frequency Earth Observation satellites at medium spatial resolution (250 m), this study investigates the feasibility of temporal monitoring of water bodies at a continental scale with MODIS.
Raphaël d’Andrimont, Pierre Defourny
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

URRENT STATE OF THE ECOSYSTEM OF LAKE UROZERO, KARELIA, ASSESSED THROUGH PRIMARY PRODUCTION AND DESTRUCTION INDICATORS

open access: yesTransactions of the Karelian Research Centre of the Russian Academy of Sciences, 2019
Lake Urozero has the status of a regional-level state hydrological nature monument in the Republic of Karelia. Up until the mid-2000’s, the lake have been noted for very high water transparency and the ultra-oligotrophic state of the ecosystem.
Elena Tekanova
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Zooplankton diversity in three water bodies of Satara District (M.S.) India

open access: yesEnvironment Conservation Journal, 2012
The present study deals with the diversity of zooplankton and physico-chemical parameters of fresh water bodies from the Satara district. The present work is carried out for 2 years from June 2006 to May 2008.
S.M. Pawar, S.R. Sonawane
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters

open access: yesFrontiers in Microbiology, 2017
The dissemination of antimicrobial resistance (AMR) is an escalating problem and a threat to public health. Comparative metagenomics was used to investigate the occurrence of antibiotic resistant genes (ARGs) in wastewater and urban surface water ...
Charmaine Ng   +10 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Biennial water management program summary

open access: yes, 1990
Water Resources Commission in cooperation with the Strategic Water Management Group.Began with [1991/1993].Some issues lack cover.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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