Results 91 to 100 of about 7,914,150 (283)

Peatlands of the Peruvian Puna ecoregion: types, characteristics and disturbance [PDF]

open access: yesMires and Peat, 2014
Peatlands represent one of the most important water resources in the Puna grassland ecoregion, but this fact is not yet widely recognised. Puna peatlands also provide key environmental services such as increasing the regional biodiversity of the Andean ...
F. Salvador, J. Monerris, L. Rochefort
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Water-related Legislation in the 2002 Virginia General Assembly

open access: yes, 2002
In 2002, the Virginia General Assembly convened on January 9 and adjourned on March 9, with a reconvened (“veto”) session on April 17. The legislature considered 2907 bills; 1587 were passed, 804 failed, and 517 were carried over to the 2003 session ...
Virginia Water Resources Research Center
core  

Chemical Assessment of Drinking Water Quality and Associated Human Health Risk of Heavy Metals in Gutai Mountains, Romania

open access: yesToxics
Chemical data compiled from field and laboratory studies were analysed on drinking water sources from a mountain area (Gutai Mountains) in Romania. Six physico-chemical indicators, nine anions, and twenty-one metals were determined and analysed.
Thomas Dippong, Maria-Alexandra Resz
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Molecular Dynamics Insights for Screening the Ability of Polymers to Remove Pesticides from Water

open access: yesChemistryOpen, 2019
The use of pesticides in agriculture is known to have environmental impacts, namely it leads to underground and spring water contamination. Thus, it turns out that nowadays general‐endeavor towards the sustainability of farmer production requires novel ...
F. G. A. Estrada   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Water Marketing-Surplus Water Reports, 2018

open access: yes, 2017
application/pdf; Report covers Calendar Year 2018; "December 2017.""Surplus water is defined as waters within the conservation water supply capacity committed to the State, but not required to meet contractual requirements.
Kansas Water Office.
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

[Status of the Kansas Water Marketing Program and the Kansas Water Assurance Program]

open access: yes, 2002
application/pdf; Title supplied by cataloger.; "The purpose of the water marketing program is to develop adequate water supply storage to meet, as nearly as practicable, present and anticipated municipal and industrial water needs through the purchase of
Kansas Water Office.
core  

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