Results 121 to 130 of about 2,321,749 (354)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A database of water chemistry in eastern Siberian rivers. [PDF]

Sci Data, 2022
Liu S, Wang P, Huang Q, Gabysheva OI, Li Z, Zhang J, Kazak ES, Liu Y, Bazarzhapov TZ, Shpakova RN, Gabyshev VA, Pozdniakov SP, Frolova NL.   +12 more
europepmc   +1 more source

Baseline Scotland : groundwater chemistry of the Carboniferous sedimentary aquifers of the Midland Valley [PDF]

, 2011
This report describes the baseline groundwater chemistry of the sedimentary aquifers of Carboniferous age in the Midland Valley of Scotland. Groundwater is an important resource in the Midland Valley, largely for agriculture, but also for industry ...
Darling, W.G., Homoncik, S., MacDonald, A.M., O Dochartaigh, B.E., Smedley, P.L.   +4 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

An examination of the influence of drained peatlands on regional stream water chemistry. [PDF]

Hydrobiologia, 2023
Pschenyckyj C, Donahue T, Kelly-Quinn M, O'Driscoll C, Renou-Wilson F.   +4 more
europepmc   +1 more source

The seasonal occurrence of the sewage fungus Leptomitus lacteus (Roth) C. Agardh in stagnant and running waters of different water chemistry of Hesse and Thuringia, Germany [PDF]

, 2006
Ale×andra Riethmüller, Andreas Gründel, Ewald Langer   +2 more
openalex   +1 more source

Simulation and Theory of Ions at Atmospherically Relevant Aqueous Liquid-Air Interfaces

, 2013
Chemistry occurring at or near the surfaces of aqueous droplets and thin films in the atmosphere influences air quality and climate. Molecular dynamics simulations are becoming increasingly useful for gaining atomic-scale insight into the structure and ...
Baer, Marcel D., Levin, Yan, Mundy, Christopher J., Stern, Abraham C., Tobias, Douglas J.   +4 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

MULTIVARIATE DATA ANALYSIS TO ASSESS GROUNDWATER HYDROCHEMICAL CHARACTERIZATION IN RAWADANAU BASIN, BANTEN INDONESIA

Rudarsko-geološko-naftni Zbornik
Multivarijantna analiza glavnih komponenata (PCA) i hijerarhijska klasterska analiza (HCA) primijenjene su za identifikaciju i klasifikaciju različitih izvora vode koji se pojavljuju u slijevu Rawadanau. Podatci uključuju 60 uzoraka uzetih tijekom sušne (
Priyo Hartanto, Rachmat Fajar Lubis, Boy Yoseph C.S.S. Syah Alam, Yoga Andriana Sendjaja, Ismawan Ismawan, T.Yan W.M. Iskandarsyah, Hendarmawan Hendarmawan   +6 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source