Results 81 to 90 of about 2,321,749 (354)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evaluation of Chemical and Physical-morphological Factors as Potential Determinants of Biomphalaria pfeifferi (Krauss, 1848) Distribution

Memorias do Instituto Oswaldo Cruz, 1997
This study was carried out in five sites along a small perennial river system in south-central Tanzania, which had been identified as the focus for transmission of intestinal schistosomiasis in the area. Malacological surveys preceding the study showed a
Jürg Utzinger, Charles Mayombana, Konstanze Mez, Marcel Tanner   +3 more
doaj   +1 more source

Interactions of adsorbed CO$_2$ on water ice at low temperatures [PDF]

, 2014
We present a computational study into the adsorption properties of CO$_2$ on amorphous and crystalline water surfaces under astrophysically relevant conditions.
Cuppen, H. M., de Wijs, G. A., Karssemeijer, L. J.   +2 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

γ-Radiolysis of the aqueous ammonia solution saturated by N2

Fushe yanjiu yu fushe gongyi xuebao
In some reactors, ammonia and its radiolytic product (H2) are used to scavenge the oxidizing species (H2O2, O2, and •OH). A reducing chemical environment is thus created and the pH of the coolant is regulated simultaneously.
GUO Zifang, ZHANG Yang, LI Yifan, LIN Zijian, LIU Chunyu, LIN Peng, LIN Mingzhang   +6 more
doaj   +1 more source

Chemistry and Radiative Transfer of Water in Cold, Dense Clouds

, 2014
The Herschel Space Observatory's recent detections of water vapor in the cold, dense cloud L1544 allow a direct comparison between observations and chemical models for oxygen species in conditions just before star formation.
Caselli, Paola, Keto, Eric, Rawlings, Jonathan   +2 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A chemistry and microbiology data set for meltwater rivers in south-western Greenland (2017–2021)

GEUS Bulletin
Meltwater rivers in Greenland transport large quantities of freshwater from the Greenland ice sheet and local glaciers to the ocean, significantly influencing marine ecosystems and global biogeochemical cycles.
Sanne M. Moedt, Kristian K. Kjeldsen, Anders R. Johnsen, Andreas P. Ahlstrøm, Christian N. Albers   +4 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

CALIDAD DEL AGUA EN POZOS DE ISLA COZUMEL, MÉXICO

Tropical and Subtropical Agroecosystems, 2011
Se analizaron in situ y en el laboratorio, variables físicas y químicas informativas de la calidad de agua subterránea de 14 pozos ubicados en el área de mayor uso de agua dulce de la isla Cozumel, Quintana Roo, México durante un ciclo anual ...
Luz de Lourdes Aurora Coronado Alvarez, M. Gutierrez, A. Cervantes   +2 more
doaj