Results 251 to 260 of about 2,317,337 (306)

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

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WATER COLUMN

Bühnentechnische Rundschau, 2023
96 Seiten, 64 Abbildungen, Englisch; 22 x 28 cm, Broschur; ISBN 78-3-907236-56-7 Edition Patrick Frey, Zürich 2023, EUR 48 ...
openaire   +1 more source

Water Columns

Leonardo, 2013
Water Columns consists of three extremely lightweight, passively actuated kinetic sculptures that take advantage of the relative tendency of wood to absorb moisture from the atmosphere to create passive engines for actuation of a long array of bi-laminate filaments.
openaire   +1 more source

Processes in the Water Column

2021
This chapter covers the processes in the water column in relation to plankton. It discusses the importance and interaction of various factors in plankton dynamics. Water motion is important for phytoplankton growth in all parts of the ocean, but its influence is best introduced in correlation with the spring phytoplankton increase.
openaire   +1 more source

Distribution of bdellovibrios in the water column of an estuary

Canadian Journal of Microbiology, 1984
The distribution of bdellovibrios in the water column of the Miles River has been studied. Water samples were collected every 4 h over a 24-h period from five depths in the water column. The samples were cultured for the recovery of bdellovibrios lytic against Vibrio parahaemolyticus.
H N, Williams, W A, Falkler
openaire   +2 more sources

Correcting for water-column variations

The Leading Edge, 2009
Marine surveys are acquired as a collection of independent sail lines that can be shot days, months, and (in the case of 4D) years apart. Even when the acquisition is well managed (for example, source and receiver positions can be accurately defined for coverage in 3D or for repeatability in 4D), one key element cannot be controlled: the properties of ...
Celine Lacombe, Suhail Butt, Graeme Mackenzie, Mark Schons, Raphael Bornard   +4 more
openaire   +1 more source

Improving the Water Column Representation

2006
Abstract : The representation of the undersea environment has often been ignored, or at best static, or precalculated in distributed simulation. This paper details the efforts of a multidisciplinary team who have implemented a dynamic ocean model and sensor response in the Joint Semi-Automated Forces (JSAF) architecture.
Nicholas Kim, Joseph Collins, Chris Scannell, Gerry Stueve, Sean Cullen, Richard Schaffer, Paul W. Maassel   +6 more
openaire   +1 more source

Shell Producers in the Water Column

1984
The key to the reconstruction of ancient pelagic environments lies largely in the sedimentary record of the shells of planktic organisms. Most important in this respect are the shells of planktic Foraminifera and Coccolithophorida. They form in places, together with shells of Pteropoda, the bulk of the present-day calcareous oozes, covering about 1/3 ...
Zeev Reiss, Lukas Hottinger
openaire   +1 more source