Results 81 to 90 of about 2,317,337 (306)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Comparison of sediment and water column nutrient processing rates in agricultural streams of contrasting buffer land use

Ecosphere
Watershed nutrient management often focuses on actions that reduce the movement of nitrogen (N) and phosphorus (P) from agricultural lands into streams. One area of management focus is the buffer of land adjacent to streams.
James H. Larson, Sean W. Bailey, Rebecca M. Kreiling, Lynn A. Bartsch, Paul C. Frost, Marguerite A. Xenopoulos, Nolan J. T. Pearce, Mary Anne Evans   +7 more
doaj   +1 more source

Calibration of the depth invariant algorithm to monitor the tidal action of Rabigh City at the Red Sea Coast, Saudi Arabia

Open Geosciences, 2020
Rabigh is a thriving coastal city located at the eastern bank of the Red Sea, Saudi Arabia. The city has suffered from shoreline destruction because of the invasive tidal action powered principally by the wind speed and direction over shallow waters ...
Aljahdali Mohammed H., Elhag Mohamed
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Uso da pressão gerada por uma coluna de água para controle da vazão em sistemas de análises em fluxo The use of pressure generated by a water column to control flow rates in flow analysis systems

Química Nova, 2007
This work presents a new approach to control the flow rate in hydrodynamic flow experiments. The combination of air pressure generated by an aquarium air pump and the pressure generated by a water column were used for this purpose. This device supports a
Wallans T. P. dos Santos, Marselha P. Ceolin, Yaico D. T. de Albuquerque, Eduardo M. Richter   +3 more
doaj   +1 more source

Use of the BT2 water line list to determine the rotational temperature and H2O column density of the circumstellar envelope on five dates [PDF]

, 2007
BT2 is the most accurate and complete synthetic water line list in existence; it includes over 505 million transitions. BT2 spectra generated at various temperatures and column densities were fitted to observed H band spectra of V838 Mon recorded on 5 ...
Ashok, N.M., Banerjee, D.P.K., Barber, R.J., Tennyson, J.   +3 more
core  

SWAS and Arecibo observations of H2O and OH in a diffuse cloud along the line-of-sight to W51 [PDF]

, 2002
Observations of W51 with the Submillimeter Wave Astronomy Satellite (SWAS) have yielded the first detection of water vapor in a diffuse molecular cloud.
David A. Neufeld, David J. Hollenbach, Elitzur M., Joulain K., Michael J. Kaufman, Paul F. Goldsmith, Rene Plume, Williams T. L.   +7 more
core   +4 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Grazing affects periphytic algal biomass in the periphyton-macrophyte relationship independently of the substrate type and nutrient status

Journal of Limnology, 2020
The macrophyte–algae relationship has primary importance in affecting the functioning of shallow lake ecosystems. However, how substratum type, grazing, and nutrient status affect the relationship, is still largely unknown.
Monika Tarkowska-Kukuryk, Wojciech Pęczuła, Tomasz Mieczan   +2 more
doaj   +1 more source