Results 61 to 70 of about 1,570,902 (266)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Open ChemistryIt is a new field to improve oil recovery by reducing the viscosity of thin oil in low permeability reservoir, which has a breakthrough significance for the development of low permeability oilfield.
Baoyu Chen +5 more
doaj +1 more source
LubricantsEnvironmental contamination critically affects the durability and performance of lubricants in machine components. Over long operating periods, particles and water ingress through degraded seals accelerate grease degradation and deteriorate tribological ...
Thi-Na Ta +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
JOIV: International Journal on Informatics VisualizationLiquefaction is a significant geological hazard in earthquake-prone locations like Padang City, Indonesia. The phenomenon happens when saturated soil loses strength owing to seismic shaking, resulting in substantial infrastructure damage.
Pakhrur Razi +3 more
doaj +1 more source
Effect of Surfactant on Water Content of Phosphogypsum
Applied Sciences, 2019 Phosphogypsum is a kind of solid waste produced in wet process of producing phosphoric acid, which affects the filtration rate and water content of phosphogypsum.
Bing Li, Hao Peng, Jing Guo
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
AgricultureLeafy vegetables, mainly lettuces, are currently the main crop cultivated in controlled environment agriculture (CEA), including vertical farming and plant factories. There is a rising demand to expand this portfolio with a wider variety of underutilized
Akvilė Viršilė +5 more
doaj +1 more source
Capacitive Imaging for Skin Characterizations and Solvent Penetration Measurements
Cosmetics, 2018 Capacitive contact imaging has shown potential in measuring skin properties including hydration, micro relief analysis, as well as solvent penetration measurements.
Xu Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source