Results 191 to 200 of about 620,018 (310)

Single-cell proteomics of Arabidopsis leaf mesophyll reveals dynamic protein responses to water-deficit stress. [PDF]

Genome Biol
Fulcher JM, Dawar P, Balasubramanian VK, Williams SM, Nadeau KD, Winkler TE, Markillie LM, Mitchell HD, Ahkami AH, Paša-Tolić L, Zhu Y.   +10 more
europepmc   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Salicylic Acid Mitigates the Effects of Water Deficit in Sour Passion Fruit in the Phenological Phases. [PDF]

Plants (Basel)
Souza AR, Soares de Lima G, Rodrigues da Silva AA, Vieira de Azevedo CA, Araújo Borborema LD, Gomes Nunes K, Costa DS, Souza Santos LF, de Lima Arruda TF, Fallé Saboya LM, Almeida Dos Anjos Soares L, Raj Gheyi H, Belo de Souza WB, Lemos da Silva FJ, de Oliveira Porto G.   +14 more
europepmc   +1 more source

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO3− Transporter ZmCLCa

Advanced Science, EarlyView.
In maize, the bHLH transcription factor ZmbHLH118 directly binds to the promoter of ZmCLCa and inhibits its expression. Tonoplast‐localized ZmCLCa mediates NO3− influx into the vacuole to regulate intracellular NO3− homeostasis, modulating nitrate uptake and metabolism, plant growth, and grain yield.
Chaonan Zhang, Elsa Demes‐Causse, Xujian Li, Zhenhui Guo, Hanshu Zhao, Huairong Cao, Yajing Song, Lijun Mu, Kaikai Zhang, Jing Zhang, Zhongtao Jia, Lixing Yuan, Alexis De Angeli, Jingbo Zhang   +13 more
wiley   +1 more source

Canopy Carbon- and Water-Use Efficiencies in Response to Temperature and Water Deficit for Wheat. [PDF]

Plant Cell Environ
Fang L, Struik PC, Yin X, Martre P.
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Organic mulching enhances Morpho-Physiological performance and yield of Sesame (Sesamum indicum L.) under water deficit conditions. [PDF]

Sci Rep
Malekiazar L, Rezaei-Chiyaneh E, Dolatabadian A, Siddique KHM.   +3 more
europepmc   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Alleviation of water-deficit inhibition of plant growth by rhizosphere microbiota conditioning. [PDF]

New Phytol
Angot V, Thiour-Mauprivez C, Schellenberger R, Lamboeuf M, Crépin O, Garmyn D, Blouin M, Jacquiod S.   +7 more
europepmc   +1 more source

Astrocytic TIA1‐Mediated Stress Granules Promote the Demyelination of Optic Neuritis by Sequestering mRNA of Cholesterol Synthesis Genes in an Experimental Autoimmune Encephalomyelitis Model

Advanced Science, EarlyView.
Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang, Xin Hua, Ziwei Fan, Jiaxin Zhao, Yuan Zhang, Qiaoyi Zhang, Xi Qu, Shengli Pan, Bingbing Wan, Shiyin Yang, Jia Li, Xu Zhang   +11 more
wiley   +1 more source