Results 31 to 40 of about 5,516,205 (303)
PlantsS. scabra is an important forage and extremophilic plant native to the Brazilian Caatinga semiarid region. It has only recently been subjected to omics-based investigations, and the generated datasets offer insights into biotechnologically significant ...
José Ribamar Costa Ferreira-Neto +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice [PDF]
International Neurourology Journal, 2018 Purpose Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect.
Eun-Jin Moon +8 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Social deprivation and exposure to health promotion. A study of the distribution of health promotion resources to schools in England [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 Chivu and ReidpathBACKGROUND: Area deprivation is a known determinant of health.
Chivu Corina M +7 more
core +2 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
DISPOSITION KINETICS OF ASPIRIN IN WATER DEPRIVATION.
, 1981 DISPOSITION KINETICS OF ASPIRIN IN WATER ...
SHAMSUL KARIM. BAKAR (7978853)
core +3 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Influence of water deprivation on the disposition of paracetamol
Journal of Pharmacy and Pharmacology, 1987 AbstractThe effect of acute (96 h) water deprivation on the disposition of paracetamol (acetaminophen) has been examined in male Sprague-Dawley rats. Plasma and urinary concentrations of the drug and its two major metabolites, the glucuronide and sulphate, were determined by a sensitive and specific high performance liquid chromatographic assay ...
N U, Zafar, S, Niazi, D, Jung
openaire +2 more sources
Tropical Animal Science JournalHeat stress, coupled with water deprivation, is widely acknowledged as one of the most potent stressors capable of impairing the production performance of small ruminants; therefore, comprehending and mitigating this stressor is of paramount importance.
E. M. Samara +3 more
doaj +1 more source