Results 41 to 50 of about 5,248,132 (284)

From Genes to Stress Response: Genomic and Transcriptomic Data Suggest the Significance of the Inositol and Raffinose Family Oligosaccharide Pathways in Stylosanthes scabra, Adaptation to the Caatinga Environment

Plants
S. scabra is an important forage and extremophilic plant native to the Brazilian Caatinga semiarid region. It has only recently been subjected to omics-based investigations, and the generated datasets offer insights into biotechnologically significant ...
José Ribamar Costa Ferreira-Neto, Manassés Daniel da Silva, Eliseu Binneck, Elayne Cristina Ramos Vilanova, Ana Luíza Trajano Mangueira de Melo, Jéssica Barboza da Silva, Natoniel Franklin de Melo, Valesca Pandolfi, Ana Maria Benko-Iseppon   +8 more
doaj   +1 more source

Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice [PDF]

International Neurourology Journal, 2018
Purpose Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect.
Eun-Jin Moon, Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Chang-Ju Kim, Hyeonjun An, Bong-Jae Lee, Jae-Woo Yi   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Psychological dominant stressor modification to an animal model of depression with chronic unpredictable mild stress

Veterinary World, 2023
Background and Aim: Chronic unpredictable mild stress (CUMS) is a protocol widely used to create an animal model of depression with food deprivation, water deprivation, and physical-dominant stressors as routine procedures.
Lisa Pangemanan, Irwanto Irwanto, Margarita M. Maramis   +2 more
doaj   +1 more source

Influence of water deprivation on the disposition of paracetamol

Journal of Pharmacy and Pharmacology, 1987
AbstractThe effect of acute (96 h) water deprivation on the disposition of paracetamol (acetaminophen) has been examined in male Sprague-Dawley rats. Plasma and urinary concentrations of the drug and its two major metabolites, the glucuronide and sulphate, were determined by a sensitive and specific high performance liquid chromatographic assay ...
N U, Zafar, S, Niazi, D, Jung
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The effect of nitric oxide on spatial learning and memory impairment following rapid eye movement (REM) sleep deprivation in rats [PDF]

مجله علوم پزشکی فیض (پیوسته), 2023
Background and Aim: Sleep deprivation causes impairment in learning and memory. Several studies have shown the positive effect of nitric oxide on learning and memory processes.
Mahdi Bodagh, Majid Taati
doaj   +2 more sources

Determining the Minimum Time Interval for Completely Eliminating the Carryover Effect of Dehydration in Heat-Stressed Goats: Insights from Physiochemical Mechanisms

Tropical Animal Science Journal
Heat stress, coupled with water deprivation, is widely acknowledged as one of the most potent stressors capable of impairing the production performance of small ruminants; therefore, comprehending and mitigating this stressor is of paramount importance.
E. M. Samara, M. A. Al-Badwi, K. A. Abdoun, A. A. Al-Haidary   +3 more
doaj   +1 more source