Advanced Science, EarlyView.GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong +11 more
wiley +1 more source
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Water deprivation-induced hypoxia and oxidative stress physiology responses in respiratory organs of the Indian stinging fish in near coastal zones. [PDF]
PeerJPati SG +4 more
europepmc +1 more source
Dataset on potential environmental impacts of water deprivation and land use for food consumption in France and Tunisia. [PDF]
Data Brief, 2019 Sinfort C +3 more
europepmc +1 more source
The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells
Advanced Science, EarlyView.Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato +9 more
wiley +1 more source
Modulation of early gene expression responses to water deprivation stress by the E3 ubiquitin ligase ATL80: implications for retrograde signaling interplay. [PDF]
BMC Plant BiolMéndez-Gómez M +3 more
europepmc +1 more source
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source
Reliability of sucrose preference testing following short or no food and water deprivation-a Systematic Review and Meta-Analysis of rat models of chronic unpredictable stress. [PDF]
Transl PsychiatryBerrio JP, Hestehave S, Kalliokoski O.
europepmc +1 more source
Key genes differential expressions and pathway involved in salt and water-deprivation stresses for renal cortex in camel. [PDF]
BMC Mol Biol, 2019 Cao Y, Zhang D, Zhou H.
europepmc +1 more source