Results 101 to 110 of about 109,030 (262)

Uromodulin Regulates Murine Aquaporin-2 Activity via Thick Ascending Limb-Collecting Duct Cross-Talk during Water Deprivation. [PDF]

Int J Mol Sci, 2022
Takata T, Hamada S, Mae Y, Iyama T, Ogihara R, Seno M, Nakamura K, Takata M, Sugihara T, Isomoto H.   +9 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Die nasionalisering van waterregte in Suid-Afrika: ontneming of onteiening? [PDF]

Potchefstroom Electronic Law Journal, 2003
THE NATIONALISATION OF WATERRIGHTS: DEPRIVATION OR EXPROPRIATION?South Africa's water law dispensation has changed dramatically with the promulgation of the National Water Act 36 of 1998.
E van der Schyff
doaj  

Water deprivation compromises maternal physiology and reproductive success in a cold and wet adapted snake Vipera berus. [PDF]

Conserv Physiol, 2021
Dezetter M, Le Galliard JF, Guiller G, Guillon M, Leroux-Coyau M, Meylan S, Brischoux F, Angelier F, Lourdais O.   +8 more
europepmc   +1 more source

Chlorine‐Functionalized Silane‐Modified Copper Electrocatalyst for Enhanced CO2 Reduction to Multi‐Carbon Products

Advanced Science, EarlyView.
A chlorine‐functionalized silane modifier (CPTMS) is introduced to cooperatively regulate CO2 reduction to C2+ products on Cu‐based catalysts. Dual‐functional interface sequentially enhances CO2 activation, intermediates protonation and C─C coupling, delivering a 5‐fold increase in C2+ faradaic efficiency (FE, 75% vs.
Ying Ying Ch'ng, Sankhadip Saha, Ming Zhang, Shujie Zhou, Lixue Jiang, Putri Ramadhany, Jitraporn Vongsvivut, Adrian Cernescu, Priyank Vijaya Kumar, Yihao Shan, Zhipeng Ma, Xiaoxuan Luo, Rahman Daiyan, Zhaojun Han, Rose Amal   +14 more
wiley   +1 more source

Water Deprivation Induces Biochemical Changes Without Reduction in the Insecticidal Activity of Maize and Soybean Transgenic Plants. [PDF]

J Econ Entomol, 2021
Silva JB, Mori R, Marques LH, Santos AC, Nowatzki T, Dahmer ML, Bing J, Gratão PL, Rossi GD.   +8 more
europepmc   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Long-duration transit and food and water deprivation alter behavioral activities and aggressive interactions at the feed bunk in beef feedlot steers. [PDF]

J Anim Sci, 2022
Heiderscheit KJ, Freestone AD, Beenken AM, Deters EL, Peschel JM, Hansen SL.   +5 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

The 3% hypertonic saline infusion test for the differential diagnosis of diabetes insipidus and primary polydipsia: assessment of diagnostic accuracy

Ожирение и метаболизм
AIM: assessment of the diagnostic accuracy of a 3% hypertonic saline infusion test in relation to a set of clinical and laboratory data (including a water deprivation test and MRI data) for differential diagnoses of diabetes insipidus (DI) and primary ...
N. N. Katamadze, E. A. Pigarova, L. K. Dzeranova, O. Yu. Rebrova, E. A. Troshina   +4 more
doaj   +1 more source