Results 31 to 40 of about 5,259,240 (283)

Social deprivation and exposure to health promotion. A study of the distribution of health promotion resources to schools in England [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 Chivu and ReidpathBACKGROUND: Area deprivation is a known determinant of health.
Chivu Corina M, Chivu, CM, Corina M Chivu, Reidpath, Daniel, Daniel D Reidpath, Chivu, Corina M, Reidpath Daniel D, Chivu, Corina, Reidpath, DD   +8 more
core   +2 more sources

A Study of Chickens During Water Deprivation

Poultry Science, 1971
Abstract Niggli and Wuhrmann (1960) described the features of electrocardiographic (ECG) changes in man during dehydration. The PR interval, QRS interval and duration of the P wave did not change significantly, but there was a decrease in amplitude of the QRS and T wave. Bierer et al.
H C, Joshi, R P, Link
openaire   +2 more sources

Water deprivation and shock thresholds [PDF]

Psychonomic Science, 1968
Thirty-two rats, under no deprivation or under 48 h water deprivation, were given 10 series of 12 different shock intensities, using the method of constant stimuli. Their reactions were classified into several categories. None of the group differences on these categories approached statistical significance, indicating that water deprivation does not ...
Robert J. Blanchard, Maurice Hayashi, Gloria Reyes   +2 more
openaire   +1 more source

From Genes to Stress Response: Genomic and Transcriptomic Data Suggest the Significance of the Inositol and Raffinose Family Oligosaccharide Pathways in Stylosanthes scabra, Adaptation to the Caatinga Environment

Plants
S. scabra is an important forage and extremophilic plant native to the Brazilian Caatinga semiarid region. It has only recently been subjected to omics-based investigations, and the generated datasets offer insights into biotechnologically significant ...
José Ribamar Costa Ferreira-Neto, Manassés Daniel da Silva, Eliseu Binneck, Elayne Cristina Ramos Vilanova, Ana Luíza Trajano Mangueira de Melo, Jéssica Barboza da Silva, Natoniel Franklin de Melo, Valesca Pandolfi, Ana Maria Benko-Iseppon   +8 more
doaj   +1 more source

Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice [PDF]

International Neurourology Journal, 2018
Purpose Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect.
Eun-Jin Moon, Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Chang-Ju Kim, Hyeonjun An, Bong-Jae Lee, Jae-Woo Yi   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Influence of water deprivation on the disposition of paracetamol

Journal of Pharmacy and Pharmacology, 1987
AbstractThe effect of acute (96 h) water deprivation on the disposition of paracetamol (acetaminophen) has been examined in male Sprague-Dawley rats. Plasma and urinary concentrations of the drug and its two major metabolites, the glucuronide and sulphate, were determined by a sensitive and specific high performance liquid chromatographic assay ...
N U, Zafar, S, Niazi, D, Jung
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source