Results 41 to 50 of about 337,947 (309)

Cardiovascular autonomic dysfunction and oxidative stress induced by fructose overload in an experimental model of hypertension and menopause [PDF]

, 2014
Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension.
Bernardes, Nathalia, Brito, Janaina de Oliveira, Conti, Filipe Fernandes, De Angelis, Kátia, Dias, Danielle da Silva, Irigoyen, Maria-Claudia, Llesuy, Susana Francisca, Malfitano, Christiane, Sanches, Iris Callado   +8 more
core   +2 more sources

Influence of water deprivation on the disposition of paracetamol

Journal of Pharmacy and Pharmacology, 1987
AbstractThe effect of acute (96 h) water deprivation on the disposition of paracetamol (acetaminophen) has been examined in male Sprague-Dawley rats. Plasma and urinary concentrations of the drug and its two major metabolites, the glucuronide and sulphate, were determined by a sensitive and specific high performance liquid chromatographic assay ...
N U, Zafar, S, Niazi, D, Jung
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determining the Minimum Time Interval for Completely Eliminating the Carryover Effect of Dehydration in Heat-Stressed Goats: Insights from Physiochemical Mechanisms

Tropical Animal Science Journal
Heat stress, coupled with water deprivation, is widely acknowledged as one of the most potent stressors capable of impairing the production performance of small ruminants; therefore, comprehending and mitigating this stressor is of paramount importance.
E. M. Samara, M. A. Al-Badwi, K. A. Abdoun, A. A. Al-Haidary   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Hormone deprivation alters mitochondrial function and lipid profile in the hippocampus [PDF]

, 2017
Mitochondrial dysfunction is a common hallmark in aging. In the female, reproductive senescence is characterized by loss of ovarian hormones, many of whose neuroprotective effects converge upon mitochondria.
Alvarez, Silvia, Astiz, Mariana, Imsen, Mercedes, Magnani, Natalia Daniela, Merino, Florencia, Reines, Analia Gabriela, Seilicovich, Adriana, Zarate, Sandra Cristina   +7 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The influence of starvation and water deprivation upon certain serum enzyme activity in chicks in the first week after hatching [PDF]

Macedonian Veterinary Review, 2009
In the past decade the determination of enzyme activity in blood serum, organs and tissues gained an innocuous meaning in the veterinary medicine, especially in the early stages of diagnosis of different metabolism abnormalities.
Markovska-Gosic Bozidarka, Dodovski Aleksandar, Stojkovski Velimir, Blagoevska Katerina, Prodanov Risto   +4 more
doaj  

Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite

Brazilian Journal of Medical and Biological Research, 2007
Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to ...
L.A. Jr De Luca, R.C. Vendramini, D.T.B. Pereira, D.A.S. Colombari, R.B. David, P.M. Paula, J.V. Menani   +6 more
doaj   +1 more source

Haematological and biochemical changes associated with male rats deprived of feed and water

Ceylon Journal of Science, 2021
Overnight food and water restriction protocols are common in animal research, however information about the haematological and biochemical changes due to food and water deprivation over longer periods can provide information about the stress experience ...
B. S. Okediran, S. A. Amid, F. Sanusi, K. O. Oladesu   +3 more
doaj   +1 more source