Advanced Science, EarlyView.The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru +15 more
wiley +1 more source
Comparative Diagnostic Performance of Copeptin After Hypertonic Saline Infusion Versus Water Deprivation Test in Pediatric Patients with Polyuria-Polydipsia Syndrome. [PDF]
Int J Mol SciCiortea DA +6 more
europepmc +1 more source
Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC
Advanced Science, EarlyView.Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen +7 more
wiley +1 more source
Water deprivation in poultry in connection with transport to slaughter-a review. [PDF]
Poult SciWurtz KE, Herskin MS, Riber AB.
europepmc +1 more source
Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling
Advanced Science, EarlyView.Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li +5 more
wiley +1 more source
Knockdown of the type 1 cannabinoid receptor in the central amygdala increases both spontaneous and water deprivation-induced sodium intake in rats. [PDF]
Am J Physiol Regul Integr Comp PhysiolRuginsk SG +5 more
europepmc +1 more source
Dynamic Supercooled Crystal–Gels for Ultrafast, Reversible Mechanical Adaptative Materials
Advanced Science, EarlyView.A dynamic supercooled crystal–gel mimics starfish tissue by storing non‐equilibrium energy in a metastable liquid. A gentle touch triggers templated crystallization, producing a 2596‐fold stiffness increase with negligible volume change. The lattice disintegrates reversibly under humidity or warmth.
Yuesong Lv +9 more
wiley +1 more source
Advanced Science, EarlyView.When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu +5 more
wiley +1 more source
Rethinking Cochlear Implants: The Need for Precise Temporal Coding
Advanced Science, EarlyView.Spatial hearing relies on sensitivity to interaural temporal cues, but this sensitivity is often poorly developed in patients with cochlear implants, particularly those with early‐onset hearing loss. Rats with cochlear implants, however, demonstrate excellent temporal sensitivity, suggesting that this limitation is not inevitable.
Nicole Rosskothen‐Kuhl +1 more
wiley +1 more source
Genotype-specific germination behavior induced by sustainable priming techniques in response to water deprivation stress in rice. [PDF]
Front Plant SciDueñas C +6 more
europepmc +1 more source