Results 71 to 80 of about 6,863,652 (336)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Dexmedetomidine ameliorates memory impairment in sleep-deprived mice

Animal Cells and Systems, 2019
The selective α2-adrenergic receptor agonist dexmedetomidine acts as an analgesic, sedative, and anesthetic adjuvant. The most common consequence of sleep deprivation is memory impairment.
Lakkyong Hwang, Il-Gyu Ko, Jun-Jang Jin, Sang-Hoon Kim, Chang-Ju Kim, Boksoon Chang, Jeong Ho Rho, Eun-Jin Moon, Jae-Woo Yi   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress

Animal Models and Experimental Medicine, 2020
Background The chronic unpredictable mild stress (CUMS) model has long been considered the best model for exploring the pathophysiological mechanisms underlying depression. However, there are no widely recognised standards for strategies for modeling and
Li‐Wen He, Li Zeng, Na Tian, Yi Li, Tong He, Dong‐Mei Tan, Qian Zhang, Yi Tan   +7 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Prenatal water deprivation alters brain angiotensin system and dipsogenic changes in the offspring

Brain Research, 2011
Objective Central renin–angiotensin system (RAS) plays an important role in regulating body fluid balance. The present study determined the effect of maternal dehydration on brain expression levels of angiotensinogen, angiotensin II receptor subtypes ...
Huiying Zhang, Yisun Fan, Fei Xia, Chunsong Geng, C. Mao, Shan Jiang, Rui He, Lubo Zhang, Zhice Xu   +8 more
semanticscholar   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

EFFECT OF FEED AND WATER DEPRIVATION ON NUTRIENTS DIGESTIBILITY, BEHAVIORAL AND METABOLIC PATTERNS OF ONE HUMPED CAMEL (Camelus dromedarius) [PDF]

Assiut Veterinary Medical Journal, 2005
Five of one humped camels of about 6 years in age and 550 kg in weight were used in this investigation. Animals appeared to be clinically healthy and parasitological examination revealed no gastrointestinal affections. The five animals forming one group,
M.A. ABDEL-RAHMAN, G.M. MOSAAD
doaj   +1 more source

Water Deprivation-Sodium Ion Toxicosis in Cattle [PDF]

Journal of Veterinary Diagnostic Investigation, 1995
In this communication, 2 cases of water deprivation/so-dium ion toxicosis in cattle are reported, illustrating the cir-cumstances of intoxication, clinical presentation, and diag-nostic approaches for this relatively uncommon syndrome.In the first case, a herd of 200 beef cow-calf pairs at pastureon May 26 were without water due to a faulty switch on ...
G D, Osweiler, T F, Carr, T P, Sanderson, T L, Carson, J A, Kinker   +4 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source