Results 31 to 40 of about 13,452,782 (251)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Applied Water Science, 2022 The hydraulic performance and future water demand of water distribution networks are major factors affecting the efficiency of water distribution systems throughout the world. Currently, Addis Kidam Town in Ethiopia is facing many water supply challenges.
Yitbarek Andualem Mekonnen
doaj +1 more source
Optimal Design of Water Distribution Network Using Two Different Metaheuristics
Chemical Engineering Transactions, 2023 Water is becoming an essential commodity for human life and is one of the most important natural resources. Public water utilities provide more than 90 percent of the world's water supply today, so a safe water distribution system is critical for any ...
Carolina Salto +5 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2021 Large amount of water is lost every day in water distribution networks (WDN) through leakage. Pressure Management by means of optimal pump operations is one vital way of leakage reduction in water distribution systems.
Tilahun, Ammanuel Bekele
core +1 more source
Results in EngineeringPopulation growth and climate change have increased the demand for freshwater resources. In Iran, the average per capita freshwater consumption is approximately 5 % to 85 % higher than the global average.
Mohamad Reza Najarzadegan, Ramtin Moeini
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Reliable Water Supply System Design under Uncertainty Case Study: Zayandehroud River Basin [PDF]
آب و فاضلاب, 2013 Water distribution network system includes multiple sources of supply and demand centers. Uncertainty in the amount of demand and supply on these systems causes many problems for decision-makers and designers.
Mahmood sabouhi sabouni, Mostafa Mardani
doaj