Results 121 to 130 of about 873,686 (310)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Flushing Duration Model for a Campaign against Contamination in Water Distribution Systems [PDF]

Contamination poses a significant risk to public health by degrading water quality in water distribution systems (WDSs). As one of the key tasks of a response strategy to contamination incidents in a WDS, pipe system flushing has been widely implemented ...
Cao, Hao, Hao Cao, Pu Li, Li, Pu
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Redundancy Features of Water Distribution Systems

, 2017
Water Distribution Systems (WDS) are traditionally built with topological and energy redundancy to improve network reliability against mechanical and hydraulic failure.
A. Di Nardo, G.F. Santonastaso, Santonastaso, G. F., MUSMARRA, Dino, D. Musmarra, V. Tzatchkov, J.M. Rodriguez Varela, Giudicianni, C., Varela, J. M. Rodriguez, DI NATALE, Michele, DI NARDO, Armando, A. Simone, M. Di Natale, C. Giudicianni, Simone, A., Tzatchkov, V.   +15 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Welfare and Distribution Effects of Water Pricing Policies [PDF]

In this paper, distribution and welfare effects of changes in block price systems are evaluated. A method is discussed to determine, for a Marshallian demand function, equivalent variation in case of a block price system. The method is applied to analyze
Arjan Ruijs
core  

First- and Second-Order Sensitivities of Steady-State Solutions to Water Distribution Systems

First-order approximations have been used with some success for criticality analysis; sensitivity analysis of physical networks, such as water distribution systems; and uncertainty propagation of model parameters.
Piller, O., Olivier Piller, Jochen W. Deuerlein, Elhay, S., Sylvan Elhay, Deuerlein, J.W., Simpson, A.R., Angus R. Simpson   +7 more
core   +1 more source

Coordinated recovery of interdependent power and water distribution systems

IET Smart Grid
The interdependent nature of power and water distribution systems (WDSs), which magnifies the impact of power outages caused by extreme weather, offers an opportunity to coordinate recovery actions towards enhancing their resilience after a major outage ...
Luis Rodriguez‐Garcia, Mathaios Panteli, Masood Parvania   +2 more
doaj   +1 more source

Sizing Behind-the-Meter Solar PV Systems for Water Distribution Networks

Engineering Proceedings
This study investigates three methods for sizing behind-the-meter (BTM) solar PV systems for pumped water distribution networks (WDNs). The three methods are (1) the industry method based on current industry practices, (2) the minimum total life cycle ...
Qi Zhao, Wenyan Wu, Jiayu Yao, Angus Ross Simpson, Ailsa Willis, Lu Aye   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source