Results 141 to 150 of about 784,267 (315)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Integrative approach to regional water schemes in South Africa [PDF]

, 2015
This article explores the use of a System Dynamics model as a boundary object in a case study regarding decision-making on water scarcity in South Africa.
van Splunter, S. (author), van Waas, R (author), Slinger, J (author)   +2 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Healthy engagement : evaluating models of providers and users for cities of the future [PDF]

, 2011
There is growing recognition within the water industry that new relationships are required that go beyond the provision of safe and healthy drinking water.
Sofoulis, Zoe, Strengers, Yolande
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Degradation and defluorination of perfluorooctane sulfonate (PFOS) forever chemical in water using hydrodynamic cavitation treatment

Chemical Engineering Journal Advances
Per- and polyfluoroalkyl substances (PFAS), also known as ''forever chemicals,'' are persistent environmental contaminants that pose significant risks to human health and aquatic ecosystems.
Amit Kumar, Anett Georgi, Ysabel Huaccallo-Aguilar, Markus Meier, Holger Kryk, Sebastian Felix Reinecke, Uwe Hampel   +6 more
doaj   +1 more source

Molecular dynamics simulation of water between two charged layers of dipalmitoylphosphatidylserine [PDF]

, 1996
A molecular dynamics simulation of water between two charged layers of dipalmitoylphosphatidylserine in its liquid-crystalline state with atomic detail was carried out.
Berendsen, H.J.C., Cascales, J.J.L., delaTorre, J.G.   +2 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Monitoring Discharge and Suspended Sediments in the Yangtze River Tidal Reach Using Coastal Acoustic Tomography

Water Resources Research
Conventional methods of measuring water discharge and suspended sediment concentration (e.g., water sampling and moving acoustic Doppler current profiler [ADCP]) present challenges in large tidal rivers due to temporal and spatial constraints. This study
Cong Xiao, Ze‐Nan Zhu, Chuanzheng Zhang, Xiao‐Hua Zhu, Yun Long Ma, Zhao‐Jun Liu, Li Xin Wei, Ji Wen Zhong, Rui Zeng, Yuan Feng Ding   +9 more
doaj   +1 more source