A Water Accounting System for Strategic Water Management [PDF]
This paper describes a water accounting system (WAS) that has been developed as an innovative new tool for strategic long-term water management. The WAS incorporates both disaggregated water use and availability, provides a comprehensive and consistent ...
Timothy M Baynes +2 more
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Pharmaceutical water systems and the 6D rule: a computational fluid dynamics analysis [PDF]
, 2003 The problem o f piping system dead-legs are frequently encountered in high purity water systems throughout the pharmaceutical and semi-conductor industries. The installation of a pipe tee in sterile process pipework often creates a stagnant dead-leg zone
Corcoran, Brian
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Patterns of water: the water related practices of households in southern England, and their influence on water consumption and demand management [PDF]
, 2013 This report contains the findings of survey research on the patterns of water using practices in households across the South and South East of England.
Anderson, B. +4 more
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Assessment of Climate Change-Induced Water Scarcity Risk by Using a Coupled System Dynamics and Bayesian Network Modeling Approaches [PDF]
The water scarcity risk induced by climate change is contributing to a sequence of hydrological and socioeconomic impacts. Certain numbers of related impacts are locked in already and are expected to be much greater in the future.
Dehghani, S +3 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
The ineffectiveness of current environmental and fire policies in the world’s largest wetland
Environmental Research LettersThe Upper Paraguay Basin (UPRB) covers 361 338 km ^2 in Brazil and can be divided into the Planalto (plateau) and the Pantanal, the largest wetland in the world.
Lucas Barros-Rosa +8 more
doaj +1 more source
Residue-Specific Structural and Dynamical Coupling of Protein and Hydration Water Revealed by Molecular Dynamics Simulations [PDF]
Proteins and their surrounding hydration water engage in a dynamic interplay that is critical for maintaining structural stability and functional integrity.
Shuai Wang, Xiakun Chu, Jun Gao
core +1 more source