Results 111 to 120 of about 784,267 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Role of Trees in Sand Dune Rehabilitation: Insights from Global Experiences
Applied SciencesThe present review summarizes the existing knowledge regarding the afforestation of sand dunes. Our main focus was on the role of trees in stabilizing and rehabilitating these complex ecosystems.
Lucian Dinca +5 more
doaj +1 more source
Dynamics and control of the Asiatic clam in the New River, Virginia [PDF]
, 1980 The Asiatic clam, Corbicula fluminea, has invaded the New River at the rate of nine miles a year from the Kanawha River, which enters downstream from the Glen Lyn coal-powered generating plant in Virginia. During the period of investigation, October 1976-
Cairns, John Jr. +3 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Flume experimental study on evolution of a mouth bar under interaction of floods and waves
Water Science and Engineering, 2019 Based on the characteristics of hydrodynamics and sediment transport in the bar area in the Modaomen Estuary, a flume experiment was performed to study the evolution of the longitudinal profile of the mouth bar.
Li Yan +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Hydrodynamic of saltwater intrusion in the Modaomen waterway
Shui kexue jinzhan, 2014 In order to study the hydrodynamic characteristics of saltwater intrusion in the Modaomen waterway,a three dimensional baroclinic numerical model with large scale and high-resolution grids,covering the entire upstream river network,the Pearl River ...
CHEN Wenlong, ZOU Huazhi, DONG Yanjun
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
The Effect of Hydration on Enzyme Activity and Dynamics [PDF]
, 2008 Water has long been assumed to be essential for biological function. To understand the molecular basis of the role of water in protein function, several studies have established a correlation between enzyme activity and hydration level. While a threshold
Lopez, Murielle
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