Results 171 to 180 of about 28,100 (309)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Freshwater monitoring across the globe: the role of citizen science within the European Water Framework Directive (WFD) and the United Nations Sustainable Development Goals (SDGs), and opportunities to incentivize the collaboration with environmental regulators. [PDF]

Open Res Eur
Gumiero B, Veronesi L, Galgani L, Cirrone RG, Corsi A, Tafi A, Loiselle SA.   +6 more
europepmc   +1 more source

Dioxin in the Elbe river basin: policy and science under the water framework directive 2000-2015 and toward 2021. [PDF]

Environ Sci Eur, 2016
Förstner U, Hollert H, Brinkmann M, Eichbaum K, Weber R, Salomons W.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A bibliometric review on the Water Framework Directive twenty years after its birth. [PDF]

Ambio
Copetti D, Erba S.
europepmc   +1 more source

Disentangling Puzzles of Spatial Scales and Participation in Environmental Governance-The Case of Governance Re-scaling Through the European Water Framework Directive. [PDF]

Environ Manage, 2016
Newig J, Schulz D, Jager NW.
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Environmental Concerns in Water Pricing Policy:   an Application of Data Envelopment Analysis (DEA) [PDF]

Water management is subject to conflicting economic and environmental objectives, and policymakers require a clear overview of the different outcomes derived from different water management options.
Giacomo Giannoccaro, Julia Martin-Ortega
core   +1 more source

Determination of pollutants, antibiotics, and drugs in surface water in Italy as required by the third EU Water Framework Directive Watch List: method development, validation, and assessment. [PDF]

Environ Sci Pollut Res Int
Colzani L, Forni C, Clerici L, Barreca S, Dellavedova P.   +4 more
europepmc   +1 more source