Results 71 to 80 of about 44,636 (306)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A solar water heater for remote communities
, 1991 The RADG has been developing a solar water heater suitable for use in remote areas. The original inspiration for this project was to provide hot water for remote Aboriginal communities.
Anda, M., Gray, E., Ho, G.
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
An appropriate technology solar water heater for remote communities
, 1989 Ill-health in Aboriginal communities exists today in modern, affluent Australia and is well documented. It appears that there has been some improvement in the infant mortality rate.
Anda, M., Ho, G.
core
Rekayasa MesinThe purpose of this research is to design and test the performance of a water heater unit that works based on the exhaust heat of the ½ PK Split Air Conditioner condenser which will be used as a power source to heat water with a capacity of 60 litres ...
Gunarto Gunarto +2 more
doaj +1 more source
Possible Waste Heat Recovery in the Condenser of a Regenerative Steam Cycle
Journal of Thermal Science and Technology, 2007 The present work is concerned with a new steam cycle proposed as a modification to the normal regenerative steam cycle. A steam ejector and an extra feed water heater are incorporated into the latter cycle.
A. S. HEGAZY
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Analysis of Lack of Fusion in Welds at Water Heaters [PDF]
Metalurgija, 2007 The paper treats a weld discontinuity called lack of fusion, which is frequently a cause of leakage of a water heater. The heater was produced by MAG welding using two wires (twin arc welding).
Tušek, J. +3 more
doaj