Results 51 to 60 of about 44,636 (306)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Water Heater.

, 1903
Patent for a water heater for use in small spaces.
Damm, William
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Langage articulé par le chauffe-eau dans La Carte et le territoire : entre l’étrangeté et l’intimité

Relief: Revue Électronique de Littérature Francaise, 2018
La dizaine d’apparitions du chauffe-eau dans La Carte et le territoire ne semble pas anodine. En contextualisant cette machine sous la plume de Houellebecq, le présent article se propose d’interpréter les liens entre le chauffe-eau et le style de l ...
Hua Hu
doaj   +5 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Optimization of aero-engine condition monitoring by autoregressive model analysis based on wireless communication

Measurement + Control
The high value of aero-engines makes it necessary to extend their life in terms of econ-omy of use. Health management is an important basis for this work.
Mai Xin, Zhifeng Ye, Xing Liu, Xiong Pan
doaj   +1 more source

Experimental study of an instantaneous-heating air source heat pump water heater with a temperature stratified water tank

Advances in Mechanical Engineering, 2016
An instantaneous-heating air source heat pump water heater with a temperature stratified water tank was put forward. The instantaneous-heating air source heat pump water heater was designed to produce hot water instantly by three modes, namely condenser ...
Mingjing Lei, Hua Zhang, Fang Wang, Xiaokuan You   +3 more
doaj   +1 more source

Legionella Infection Risk from Domestic Hot Water

Emerging Infectious Diseases, 2004
We investigated Legionella and Pseudomonas contamination of hot water in a cross-sectional multicentric survey in Italy. Chemical parameters (hardness, free chlorine, and trace elements) were determined. Legionella spp.
Paola Borella, M. Teresa Montagna, Vincenzo Romano-Spica, Serena Stampi, Giovanna Stancanelli, Maria Triassi, Rachele Neglia, Isabella Marchesi, Guglielmina Fantuzzi, Daniela Tatò, Christian Napoli, Gianluigi Quaranta, Patrizia Laurenti, Erica Leoni, Giovanna De Luca, Cristina Ossi, Matteo Moro, Gabriella Ribera D’Alcalà   +17 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source