Results 101 to 110 of about 6,521,310 (287)

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

1998 General Assembly Legislation Related to Water

, 1998
The Virginia General Assembly held its regular session from January 14 to March 17, then reconvened April 22-23 to respond to the governor’s vetoes.
Manfre, Joseph, Virginia Water Resources Research Center   +1 more
core  

Insights into Water Inflow Mechanisms from Roof Aquifers: Analytical Solution of the Ditch Inflow Model

Water inflow from roof aquifers is a critical parameter in longwall mining, which greatly affects mine safety. Existing analytical methods, such as the large well method, can only provide single-value predictions and fail to reveal the underlying ...
Song, Jiawei, Hu, Yongsheng, Chen, Luwang, Lacidogna, Giuseppe, Ou, Qinghua, Hou, Xiaowei   +5 more
core   +1 more source

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

Mechanisms behind consolidation-induced water release from effective impermeable soil layers and mine water inflow prediction in coal mining

Meitian dizhi yu kantan
BackgroundIn the Yushen mining area, coal mining is gradually shifting toward areas with thick soil layers. This leads to continuous water release from the saturated soils above the hydraulically conductive fracture zones, thereby significantly ...
Tao LI, Ying GAO, Limin FAN, Junwei YANG
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Prediction of Construction Water Inflow of Karst Water-Rich Tunnel Without Drainage Tunnel

AbstractThe construction of infrastructure in China faces substantial challenges due to the complex geological conditions and groundwater in karst areas, particularly in tunnel construction. The construction of the Maoping Port railway tunnel in the Three Gorges Hub area has been accompanied by the emergence of caves and faults.
Wei Li, Shiquan Hao, Ju Wang, Junpeng Zou   +3 more
openaire   +1 more source

Active Oscillations of Elastic Membranes Arising from the Coupling with a Catalytic Reaction

Advanced Science, EarlyView.
Coupling an elastic membrane to a catalytic reaction produces active oscillations that self‐sustain for hours: the membrane cyclically inflates and deflates as the reaction spontaneously activates and deactivates, without external power. Energy release is directly embodied in the oscillation dynamics, opening elasto‐chemical strategies for the physical
Alberto Comoretto, Samuel D. Gollob, Erik Steur, Kaitlyn P. Becker, Ellen T. Roche, Johannes T.B. Overvelde   +5 more
wiley   +1 more source

Water-related Legislation in the 2002 Virginia General Assembly

, 2002
In 2002, the Virginia General Assembly convened on January 9 and adjourned on March 9, with a reconvened (“veto”) session on April 17. The legislature considered 2907 bills; 1587 were passed, 804 failed, and 517 were carried over to the 2003 session ...
Virginia Water Resources Research Center
core  

Improving a Prediction Model for Tunnel Water Inflow Estimation Using LSTM and Bayesian Optimization

Water inrush and mud burst disasters pose severe challenges to the safe and efficient construction of underground engineering. Water inflow prediction is closely related to drainage design, disaster prevention and control, and the safety of the ...
Tao Sun, Xiaojun Zhang, Zishuai Yang, Zhenpeng Wang, Kui Zhao, Lijian Ma, Haigang Li, Yu Zheng, Yun Wu, Zhen Huang   +9 more
core   +1 more source