Results 121 to 130 of about 6,521,310 (287)

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Water Marketing-Surplus Water Reports, 2018

, 2017
application/pdf; Report covers Calendar Year 2018; "December 2017.""Surplus water is defined as waters within the conservation water supply capacity committed to the State, but not required to meet contractual requirements.
Kansas Water Office.
core  

Water flow between Ohau Channel and Lake Rotoiti following implementation of a diversion wall. [PDF]

, 2009
The water quality in Lake Rotoiti has become increasingly degraded since the 1950s. Water from Lake Rotorua, with elevated phytoplankton and nutrient concentrations, has entered Lake Rotoiti via the Ohau Channel.
Immenga, Dirk, McBride, Chris G., Paul, Wendy J., Hamilton, David P.   +3 more
core  

Comparison of N-BEATS with Standalone and Hybrid Deep Learning Models in Monthly Inflow Forecasting to the Aras Dam Reservoir: A Feature Selection Analysis

Journal of Agricultural Sciences
Reservoir dams play a pivotal role in water resource management. Accurate prediction of inflow to reservoirs significantly enhances operational performance.
Elman Athari, Mohammad Taghi Aalami, Mohammad Taghi Sattari   +2 more
doaj   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam, Yong Kwon Chae, Seoung‐Jin Hong, Younggen Lee, Dongwook Yang, Byunggi Kim, Sang Wook Kang, Young‐Jin Kim   +7 more
wiley   +1 more source

Hydraulic characteristics and flow trajectories under two-sided asymmetric inflow conditions for a deep storage tunnel system

Water Science and Engineering
Deep storage tunnels (DSTs) are used in densely urbanized areas to relieve stormwater collection systems, thereby reducing urban floods and runoff pollution, due to their substantial storage capacity.
Wei He, Chao Yu, Xiao-dong Yu, Jian Zhang, Jose G. Vasconcelos, Hui Xu, Shou-ling Chen   +6 more
doaj   +1 more source

The role of venture‐financed startups in innovation for US agriculture

American Journal of Agricultural Economics, EarlyView.
Abstract To evaluate the role played by startup companies in the innovation ecosystem of US agriculture, we compile a unique dataset of 6024 new entrants founded 1987–2019 that details their financing lifecycles, annual economic performance, and patenting activities.
Gregory D. Graff, Charles A. W. de Grazia, Nicholas E. Rada   +2 more
wiley   +1 more source

Water-rich zoning and water quantity prediction of coal seam in Balasu Mine Field

Meikuang Anquan
According to the special form of water occurrence and migration in No.2 coal seam of Balasu Coal Mine in northern Yuheng Mining Area of Jurassic Coal Field in northern Shaanxi province, through theoretical analysis, calculation and prediction, simulation
Gang FANG
doaj   +1 more source