Results 61 to 70 of about 6,521,310 (287)

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Dynamic prediction method of tunnel water inflow based on detailed depiction of complex geological bodies

, 2023
It is a challenge to accurately characterize the irregular geological bodies and underground structures such as inclined faults and inclined tunnels during the numerical simulation of tunnel water inflow prediction, and the prediction generally assumes ...
Yazhe, LI, Hui, QIAN, Qingbo, LI, Fengwei, YANG, Yajun, DU, Weifeng, WAN   +5 more
core   +1 more source

Prediction of Water Inflow from Working Face Based on Numerical Model of Drainage Ditch

Meikuang Anquan, 2020
The prediction of water inflow from coal mining face is the basis for the prevention and control of water in the production process of coal mines. Through the generalization of hydro-geological conditions in coal mine goaf, combined with the analysis of ...
GUO Xiaoming
doaj   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Predicting mine water inflow volumes using a decomposition-optimization algorithm-machine learning approach

Scientific Reports
Disasters caused by mine water inflows significantly threaten the safety of coal mining operations. Deep mining complicates the acquisition of hydrogeological parameters, the mechanics of water inrush, and the prediction of sudden changes in mine water ...
Jiaxin Bian, Tao Hou, Dengjun Ren, Chengsen Lin, Xiaoying Qiao, Xiongde Ma, Ji Ma, Yue Wang, Jingyu Wang, Xiaowei Liang   +9 more
doaj   +1 more source

Application of Hybrid Gamma-SVM Approach for River Flow Prediction in Zarinehrud Basin [PDF]

محیط زیست و مهندسی آب, 2018
Prediction of river flow is an important issue in planning water resources and management of supply and demand in future conditions. Hence, it has attracted researchers’ notice due to its importancein the designing, planning, management and operation of ...
Abbas Abbasi, Mahid Delavar, Saeed Morid
doaj  

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Prediction of Mine Water Inflow Based on Growth Curve Model

Academic Journal of Science and Technology
During the construction and operation of a coal mine, water inrush incidents frequently occur. Minor water-related accidents can cause delays in mining operations, while major incidents can result in significant losses and casualties. This paper takes a coal mine in Shanxi as a case study, employing growth curve models and optimal weighted coefficient ...
Shang Wang, Qingge Zhang, Shiyuan Tian
openaire   +1 more source

Structural Control Over Bicontinuous Emulsions from Solvent‐Transfer Induced Phase Separation Through Nanoparticle Loading

Advanced Science, EarlyView.
The nanoparticle loading enables effective control over the liquid domain size in bicontinuous interfacially jammed emulsion gels (bijels) produced through solvent‐transfer induced phase separation (STrIPS). The relationship between the nanoparticle loading and domain size profiles in STrIPS bijels is resolved through confocal microscopy and explained ...
Jesse M. Steenhoff, Martin F. Haase
wiley   +1 more source