Results 71 to 80 of about 6,385 (284)

Quantifying the effects of future environmental changes on water supply and hydropower generation benefits of cascade reservoirs in the Yellow River Basin within the framework of reservoir water supply and demand uncertainty

Journal of Hydrology: Regional Studies
Inflow and water demand prediction plays an important role in reservoir operation rulemaking. Uncertainties in meteorological and hydrological modeling increase the complexity of inflow and water demand prediction, which are not sufficiently considered ...
Shuai Zhou, Yimin Wang, Jianxia Chang, Hui Su, Qiang Huang, Ziyan Li   +5 more
doaj   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Application of Hybrid Gamma-SVM Approach for River Flow Prediction in Zarinehrud Basin [PDF]

محیط زیست و مهندسی آب, 2018
Prediction of river flow is an important issue in planning water resources and management of supply and demand in future conditions. Hence, it has attracted researchers’ notice due to its importancein the designing, planning, management and operation of ...
Abbas Abbasi, Mahid Delavar, Saeed Morid
doaj  

Prediction of Mine Water Inflow based on the Coupled Flow Characteristics of Multiple Water Conducting Structures

, 2022
Abstract Because of various patterns of deep-water inrush and complicated mechanism, accurate prediction of mine water inflow is always a difficult problem for coal mine geologists. In this paper, the water inrush channel is divided into four basic water diversion structures: aquifer, rock fracture zone, fracture zone and goaf.
Jinhai Zhao, Qi Liu, Changbao Jiang, Defeng Wang   +3 more
openaire   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Development of a Revised Multi-Layer Perceptron Model for Dam Inflow Prediction

, 2022
It is necessary to predict dam inflow in advance for flood prevention and stable dam operations. Although predictive models using deep learning are increasingly studied, these existing studies have merely applied the models or adapted the model structure.
Joong Hoon Kim, Hyeon Seok Choi, Eui Hoon Lee, Sun-Kwon Yoon   +3 more
core   +1 more source

Prediction of Mine Water Inflow Based on Growth Curve Model

Academic Journal of Science and Technology
During the construction and operation of a coal mine, water inrush incidents frequently occur. Minor water-related accidents can cause delays in mining operations, while major incidents can result in significant losses and casualties. This paper takes a coal mine in Shanxi as a case study, employing growth curve models and optimal weighted coefficient ...
Shang Wang, Qingge Zhang, Shiyuan Tian
openaire   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Numerical model construction and application exploration of fault zone structure based on borehole data

Meitan xuebao
The accurate construction and parameter assignment of fault zone numerical models have long been a challenge faced by coal mine geologists. The prediction of inflow from fault zones during mining activities is complicated by issues such as structural ...
Jinhai ZHAO, Weilong ZHU, Wenbin SUN, Hailong MA, Yang QIAO   +4 more
doaj   +1 more source