Results 91 to 100 of about 14,982,501 (348)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Development of a Uniform Alginate-Based Coating for Cantaloupe and Strawberries and the Characterization of Water Barrier Properties

Foods, 2019
Water loss, gain or transfer results in a decline in the overall quality of food. The aim of this study was to form a uniform layer of sodium alginate-based edible coating (1.25% sodium alginate, 2% glycerol, 0.2% sunflower oil, 1% span 80, 0.2% tween 80,
Tugce Senturk Parreidt, Martina Lindner, Isabell Rothkopf, Markus Schmid, Kajetan Müller   +4 more
doaj   +1 more source

Bending the Curve of Global Freshwater Biodiversity Loss: An Emergency Recovery Plan

BioScience, 2020
Despite their limited spatial extent, freshwater ecosystems host remarkable biodiversity, including one-third of all vertebrate species. This biodiversity is declining dramatically: Globally, wetlands are vanishing three times faster than forests, and ...
D. Tickner, J. Opperman, R. Abell, M. Acreman, A. Arthington, S. Bunn, S. Cooke, J. Dalton, W. Darwall, Gavin Edwards, I. Harrison, Kathy A. Hughes, T. Jones, D. Leclère, A. Lynch, P. Leonard, M. McClain, D. Muruven, J. Olden, S. Ormerod, James Robinson, R. Tharme, M. Thieme, K. Tockner, Mark D Wright, L. Young   +25 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Study the Mass Transfer Kinetics of Aloe vera Gel Cubes

Journal of Pure and Applied Microbiology, 2017
The present study was carried out to investigate the mass transfer kinetics of Aloe Vera gel cubes during osmo-convective and convective drying and its quality evaluation.
Shalini, Jaivir Singh, Ravi Kumar, Zarka Danish, Tarun Kumar, Ankit Sharma , Ankit Singh   +6 more
doaj   +1 more source

Loss Aversion in Water Markets [PDF]

Resource /Energy Economics and Policy,
Ranjan, Ram, Shogren, Jason F.
core   +1 more source

Phytocytokine signalling reopens stomata in plant immunity and water loss

Nature, 2022
Zunyong Liu, Shuguo Hou, Olivier Rodrigues, Ping Wang, Dexian Luo, S. Munemasa, Jiaxin Lei, J. Liu, F. A. Ortiz-Morea, X. Wang, K. Nomura, Chuanchun Yin, Hongbo Wang, Wei Zhang, K. Zhu‐Salzman, S. He, Ping He, Libo Shan   +17 more
semanticscholar   +1 more source

The new assessment of soil loss by water erosion in Europe

, 2015
Soil erosion by water is one of the major threats to soils in the European Union, with a negative impact on ecosystem services, crop production, drinking water and carbon stocks.
Panos Panagos, P. Borrelli, J. Poesen, C. Ballabio, E. Lugato, K. Meusburger, L. Montanarella, C. Alewell   +7 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Enhancing the quality of pear candies via jaggery‐based osmotic dehydration: Optimization and analysis

Future Postharvest and Food
Pear (Pyrus pyrifolia) is a healthy fruit; however, its availability is limited in certain seasons due to short shelf life. To overcome this limitation, a cost‐effective dehydration‐based preservation involving osmotic dehydration process with jaggery as
Gurpreet Dhillion, Amardeep Kour, Navjot Gupta, Padma Nath Atreya   +3 more
doaj   +1 more source