Results 111 to 120 of about 18,687 (301)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Investigating the Effect of Water Contamination on Gearbox Lubrication based upon Motor Control Data from a Sensorless Drive

Water is one of the most significant destructive contaminations to lubricants which in turn lead to more power consumption and early damage to rotating machines.
Gu, Fengshou, Brethee, Khaldoon F., Ball, Andrew, Benghozzi, Ahmed, Abusaad, Samieh   +4 more
core  

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Fluid–Structure Interaction Mechanisms of Layered Thickness Effects on Lubrication Performance and Energy Dissipation in Water-Lubricated Bearings

Lubricants
Traditional single-layer water-lubricated rubber or plastic bearings suffer from water film rupture, excessive frictional losses, and insufficient load-carrying capacity, which limit performance and service life in marine propulsion and ocean engineering.
Lun Wang, Xincong Zhou, Hanhua Zhu, Qipeng Huang, Zhenjiang Zhou, Shaopeng Xing, Xueshen Liu   +6 more
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Escoamento de óleo e refrigerante pela folga pistão-cilindro de compressores herméticos alternativos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.O conhecimento do processo de lubrificação das partes móveis dos compressores alternativos herméticos, sobretudo do pistão, é ...
Dias, João Paulo
core  

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

FRICTION BEHAVIOURS OF LUBRICATION OIL CONTAMINATED WITH COOLING WATER IN MARINE DIESEL ENGINES

, 2018
Lubrication is used for both cooling and lubricating in marine diesel engines which are used for producing electricity and propulsion system on ships. Furthermore, lubrication oil is cooled with both sea water and fresh water in conventional and central ...
Kökkülünk, Görkem, Aydın, Zafer, Okumuş, Fatih, G. KÖKKÜLÜNK, SEFER YILMAZ, H. ELÇİÇEK, Elçiçek, Hüseyin, F. OKUMUŞ   +7 more
core   +1 more source

Integrated Hydrophilic Interdigitated Network for Silicone Rubber via a Gradient Polarity Modification Strategy

Advanced Science, EarlyView.
This work overcomes the long‐standing challenge of hydrophilic modification of silicone rubber via a gradient polarity modification strategy. By constructing a hydrophilic interpenetrating network within cured SR, simultaneous surface‐to‐bulk modification is achieved while enabling monitoring through a Eu3+ complex fluorescent tracer.
Lihui Zhang, Rui Wang, Pingru Su, Yao Kou, Zhengfeng Ma, Hui Tang, Mingying Wang, Lixin Wang, Chunyu Zhou, Shuanhong Ma, Yu Tang, Feng Zhou   +11 more
wiley   +1 more source