Results 41 to 50 of about 1,190,304 (309)

Technology for whom? Solar irrigation pumps, women, and smallholders in Nepal

Frontiers in Sustainable Food Systems, 2023
Agricultural technologies are often promoted as a medium for women’s economic empowerment, which can transform unequal gender relations in rural agrarian societies.
Gitta Shrestha, Gitta Shrestha, Labisha Uprety, Manohara Khadka, Aditi Mukherji   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of irrigation network rehabilitation on water management-case study: Tanta Navigation canal – Egypt

Alexandria Engineering Journal, 2019
Tanta Navigation canal is a 38.0 km long main canal serving 65,000 ha. in the Nile Middle Delta of Egypt. The main branch of Tanta canal is El-Kased canal with 34.0 km long, and serving 60% of Tanta Canal served area.The main problem was the inability to
Talaat ElGamal, Mohamed ElFetyany, Gamal ElKassar   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ground-water management

California Agriculture, 1977
If adequate water supplies are to be continually available, and if Periods Of drought are to be dealt with effectively, management of ground water is essential on every farm and in every city county, water district, and region using ground-water ...
V Scott, J Scalmanini
doaj  

An integrated modeling framework for water accounting assessment in the Lake Tana Sub-Basin, Ethiopia: Impacts of interbasin water transfer

Journal of Hydrology: Regional Studies
Study Region: Lake Tana Sub-Basin, Ethiopia Study Focus: The Lake Tana sub-basin plays a vital role in Ethiopia’s hydropower generation and irrigation development.
Kirubel Mekonnen, Naga Manohar Velpuri, Mansoor Leh, Komlavi Akpoti, Afua Owusu, Smaranika Mahapatra, Primrose Tinonetsana, Lahiru Madushanka, Tharindu Perera, Hailay Zeray Tedla, Mamaru Talema, Abdulkarim Seid   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Factors affecting willingness to adopt climate insurance among smallholder farmers in Sri Lanka

Climate Risk Management, 2023
Drought is an almost annual phenomenon affecting many parts of Sri Lanka, causing huge damage to agriculture and losses to the broader economy in general and farmers in particular. Climate change threatens to exacerbate these risks.
Mohamed Aheeyar, Upali Amarasinghe, Giriraj Amarnath, Niranga Alahacoon   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessing framing of uncertainties in water management practice

, 2009
Dealing with uncertainties in water management is an important issue and is one which will only increase in light of global changes, particularly climate change.
Nicola Isendahl, Sabine Möllenkamp, Art Dewulf, Francois, G., Claudia Pahl-Wostl, Brugnach, M., Pahl-Wostl, C., Brugnach, Marcela Fabiana, Marcela Brugnach, De Wulf, A., Greet François, Isendahl, N., Dewulf, A., Möllenkamp, S.   +13 more
core   +1 more source