Results 71 to 80 of about 1,501,393 (262)

Water Mass Archaeology: Tracing water masses to the surface

WP5 investigates how ice sheet meltwater discharge affects deep water formation, pole-to-pole connections, and large-scale ocean circulation, including the AMOC and ACC. It combines new ocean observations, innovative analyses, and modelling approaches to better understand how freshwater influences the global climate system.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Rapid Determination of Calcium Ions in Water by Microwave Plasma Torch-Mass Spectrometry Coupled with Pneumatic Nebulization

Yankuang ceshi, 2015
Metal element contents in water samples are commonly determined by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). ICP-MS has a low detection limit and wide linear range, but has a high power, large gas consumption, and high cost.
YANG Mei-ling, ZHONG Tao, PEI Miao-rong, ZHANG Xing-lei, LE Zhang-gao, WANG Guang-cai, CHEN Huan-wen   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Water Mass and Indirect Estimation of Turbulent Mixing Based on Observational CTD Yoyo Data in Flores Sea Waters, Indonesia

Jurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract   Highlight Research • Three distinct water layers were identified: surface (0-50 m), thermocline (50-180 m), and deep (>180 m).
Gentio Harsono, Amir Yarkhasy Yuliardi, Anindya Wirasatriya, Budi Purwanto, Mario Cabral   +4 more
doaj   +1 more source

Invited perspectives: Integrating hydrologic information into the next generation of landslide early warning systems [PDF]

Natural Hazards and Earth System Sciences
Although rainfall-triggered landslides are initiated by subsurface hydro-mechanical processes related to the loading, weakening, and eventual failure of slope materials, most landslide early warning systems (LEWSs) have relied solely on rainfall event ...
B. B. Mirus, B. B. Mirus, T. Bogaard, R. Greco, M. Stähli   +4 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Effect of Environmental Conditions on Copepod Size Structure and Energy Flux in the Pelagic Ecosystem of the Kuril Islands Region

Biology
Spatial and vertical variations in copepod abundance, carbon biomass, and size spectra are analyzed to elucidate the effects that the highly variable oceanographic conditions of the environment around the Kuril Islands exerted on the copepod size ...
Valentina Kasyan
doaj   +1 more source

Risk–Benefit Assessment of Monomethylmercury and Omega-3 Fatty Acid Intake for Ringed Seal Consumption with Particular Emphasis on Vulnerable Populations in the Western Canadian Arctic

Frontiers in Nutrition, 2017
Many northern Inuit communities rely on traditional food as major source of nourishment. An essential part of the traditional Arctic diet is marine mammals such as ringed seals or beluga.
Lena Gmelch, Lena Gmelch, Holger Hintelmann, Brendan Hickie, Hermine Kienberger, Gary Stern, Michael Rychlik, Michael Rychlik   +7 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source