Results 281 to 290 of about 827,643 (333)

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

Biotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya, Rajesh K. Mistry, Susie Sou, Sonja Hess, Bijay Khanal, Zayla Schaeffer, Jie Zhu, Lina Chakrabarti   +7 more
wiley   +1 more source

A river in crisis: water quality, microbial burden, and public health implications of a South African urban river. [PDF]

Appl Environ Microbiol
Duze ST, Mkhize L, Marimani M, Patel M.
europepmc   +1 more source

Microbiological quality of drinking water in three rural communities of the Calvas County – Loja

Estíbaliz Loza, Majo Carrasco-Tenezaca, Anita G. Villacís, Francisco Pardo, César A. Yumiseva   +4 more
openalex   +2 more sources

Analysis of the economic viability and environmental impacts of a conceptual process model for the recovery of lactic acid from spent media in cultivated meat production

Biotechnology Progress, EarlyView.
Abstract Scaled production of cultivated meat (CM) will co‐produce large volumes of spent media. Recycling of abundant metabolites such as lactic acid in spent media offers an opportunity for valorization and reduction of the carbon footprint of CM production; however, the feasibility has yet to be examined.
Josh Wimble, Reina Ashizawa, Elliot W. Swartz   +2 more
wiley   +1 more source

Are hospital environments an underestimated source for Gram-negative infections in critically ill patients? A non-multi-drug-resistant <i>Klebsiella pneumoniae</i> outbreak in an Irish intensive care unit. [PDF]

Infect Prev Pract
Ali S, Macori G, Mullane N, Jayaseelan B, Donoghue O, Fanning S, Schaffer K.   +6 more
europepmc   +1 more source

Dynamics of natural killer cell function upon recurrent stimulation

Biotechnology Progress, EarlyView.
Weekly stimulation of peripheral blood‐derived NK cells with engineered K562 feeder cells resulted in two distinct growth phases, shifting around Day 21–26. Cells in growth phase 2 exhibited slower growth, reduced metabolic activity, and lower cytotoxicity than cells from growth phase 1, which has implications for NK cell biomanufacturing.
Jennifer One, Janani Narayan, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin   +4 more
wiley   +1 more source

Isolation and Identification of Pathogenic Bacteria Present in Commercially Important Fish, Shellfish, Water, and Soil Samples of Kaptai Lake, Bangladesh. [PDF]

Environ Microbiol Rep
Chakma S, Barua H, Akter A, Afroze S, Faisal M, Khan NA.   +5 more
europepmc   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

Effectiveness of Ozone Treatment, Ultrasonic Treatment, and Ultraviolet Irradiation in Removing <i>Candida albicans</i> Adhered to Acrylic Resins Fabricated by Different Manufacturing Methods. [PDF]

Materials (Basel)
Kaneko C, Sawada T, Ishikawa T, Miura T, Kobayashi T, Takemoto S.   +5 more
europepmc   +1 more source

Performance of large virus removal filters during AAV processing: Influence of flux and process disruptions

Biotechnology Progress, EarlyView.
Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal, Asingsa W. Arachchige, Annabelle J. Zahn, S. Ranil Wickramasinghe, Xianghong Qian, Andrew L. Zydney   +5 more
wiley   +1 more source