Results 61 to 70 of about 1,280,375 (291)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Stainless steel made to rust: a robust water-splitting catalyst with benchmark characteristics [PDF]

, 2015
The oxygen evolution reaction (OER) is known as the efficiency-limiting step for the electrochemical cleavage of water mainly due to the large overpotentials commonly used materials on the anode side cause.
Anindita, Bard, Biesinger, Biesinger, Bockris, Bode, Burke, Cerny, Chemelewski, Chen, Chien, Cocijan, Cook, Cordoba, Davidson, Diemo Daum, El-Deab, Gennero De Chivalo, Gorlin, Grimaud, Grosvenor, Haase, Helmut Schäfer, Jiao, Joachim Wollschläger, Jörg Hardege, Karsten Kuepper, Kessler, Klewe, Lee, Lee, Leonard, Lian, Lilli Schneider, Lorenz Walder, Louie, Lyons, Lyons, Lyons, Lyons, Lyons, Martin Steinhart, Medway, Meyer, Miles, Moureaux, Najafpour, Nakagawa, Ngamlerdpokin, O'Grady, Petrykin, Prasad Srirapu, Ptacek, Qiu, Rossmeisl, Rossmeisl, Sato, Scarr, Schäfer, Schäfer, Shamaila Sadaf, Singh, Singh, Singh, Stephan Dinklage, Suntivich, Trasatti, Trasatti, Trasatti, Trotochaud, Trotochaud, Tseung, Uhlenbrock, Walter, Wang, Zhao, Zhou, Zhou, Zou   +78 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Molecular CO2 Reduction Catalyst Based on Giant Polyoxometalate {Mo368}

Frontiers in Chemistry, 2018
Photocatalytic CO2 reduction in water is one of the most attractive research pursuits of our time. In this article we report a giant polyoxometalate {Mo368} based homogeneous catalytic system, which efficiently reduces CO2 to formic acid with a maximum ...
Santu Das, Santu Das, Tuniki Balaraju, Tuniki Balaraju, Soumitra Barman, Soumitra Barman, S. S. Sreejith, S. S. Sreejith, Ramudu Pochamoni, Ramudu Pochamoni, Soumyajit Roy, Soumyajit Roy   +11 more
doaj   +1 more source

Macrocyclic cyanocobalamin (vitamin B12) as a homogeneous electrocatalyst for water oxidation under neutral conditions

, 2020
Highly water-soluble cyanocobalamin (also known as vitamin B-12) is the most structurally macrocyclic complex comprising cobalt in the center of a corrin ring.
Ahmad, Nazir, Shahadat, Hossain M, Verpoort, Francis, Younus, Hussein A, Zhang, Shiguo, Zhuiykov, Serge   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Synergistic Water Oxidation with Low-Energy Light via Ru(bda)(pic)₂ and a Tetranuclear Ruthenium Dendrimer

Applied Sciences
The synergistic combination of the ruthenium-based tetranuclear dendrimer photosensitizer with the highly efficient water oxidation catalyst Ru(bda)(pic)2 enables effective water oxidation under low-energy light irradiation in phosphate buffer 20 mM ...
Ambra Maria Cancelliere, Fausto Puntoriero, Alessandro Amadeo, Giuseppina La Ganga, Francesco Nastasi   +4 more
doaj   +1 more source

Structural Changes in the Acceptor Site of Photosystem II upon Ca²⁺/Sr²⁺ Exchange in the Mn₄CaO₅ Cluster Site and the Possible Long-Range Interactions

Biomolecules, 2019
The Mn4CaO5 cluster site in the oxygen-evolving complex (OEC) of photosystem II (PSII) undergoes structural perturbations, such as those induced by Ca2+/Sr2+ exchanges or Ca/Mn removal.
Faisal Hammad Mekky Koua
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Photoelectrochemical Response of WO3/Nanoporous Carbon Anodes for Photocatalytic Water Oxidation

C, 2018
This work demonstrates the ability of nanoporous carbons to boost the photoelectrochemical activity of hexagonal and monoclinic WO3 towards water oxidation under irradiation.
Alicia Gomis-Berenguer, Jesús Iniesta, David J. Fermín, Conchi O. Ania   +3 more
doaj   +1 more source