Results 131 to 140 of about 6,491,565 (281)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Toward Optimal Irrigation Management at the Plot Level: Evaluation of Commercial Water Potential Sensors. [PDF]
Sensors (Basel), 2023 Aldaz-Lusarreta A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Water relations in seed biology
Scientia Agricola, 1998 The water relations play a fundamental role in seed biology. Thus, the purpose of the present paper was to analyze the performance of water status in seed development and germination.
Villela F. A.
doaj
Measuring tissue water potential in marine macroalgae via an updated Chardakov method. [PDF]
AoB Plants, 2023 Gibson VL, Richards Donà A, Smith CM.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Study of radionuclide composition of the drinking water potential sources at the Semipalatinsk nuclear test site. [PDF]
RSC Adv, 2023 Krasnopyorova M +4 more
europepmc +1 more source
The prospects of rainwater harvesting in the Ho CHi Minh City [PDF]
, 2015 Wisely using natural water resources to serve human needs plays a decisive role in ensuring water and food security. In the natural water cycle, rainwater is considered as a valuable renewable resource.
Dao, Phan +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source