Results 81 to 90 of about 2,486,223 (263)

Efeito do sistema de condução em algumas características ecofisiológicas da videira (Vitis labrusca L.) Effect of the conduction system in some ecophysiological features of vine

open access: yesCiência e Agrotecnologia, 2009
Os efeitos da interação entre a forma do dossel vegetativo e os fatores ambientais locais resultam no microclima que determinará alterações em alguns aspectos fisiológicos da videira, podendo afetar significativamente o crescimento vegetativo, a ...
Paulo Márcio Norberto   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Determination of the Water Potential Threshold at Which Rice Growth Is Impacted

open access: yesPlants, 2018
Rice feeds 50% of the world’s population. Flooding is the most common irrigation system used for growing rice, a practice responsible for a large amount of water loss.
Caio Luiz dos Santos   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Emergência e crescimento inicial de plantas de arroz e capim-arroz em função do nível de umidade no solo Initial emergence and growth of rice and Echinochloa sp. plants as a function of soil water level

open access: yesPlanta Daninha, 2007
Em anos de baixa precipitação durante o período pós-semeadura, as plantas de capim-arroz tendem a emergir primeiro que as de arroz, promovendo maior competição inicial com a cultura.
G. Concenço, N.F. Lopes, A. Andres
doaj   +1 more source

Sustainable Management of Alpine Water Potentials

open access: yesRevue de géographie alpine, 2005
Abstract : In Europe the need for high-quality freshwater has been increasing by a factor often since the beginning of the 20th century. Due to their geographic position and topographic feature the Alps are a major freshwater collector and hydrological storage system.
Meissner, Simon, Relier, Armin
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

GEOINFORMATION-CARTOGRAPHIC MODELING OF WATER AVAILABILITY FOR WATER SECURITY AND SUSTAINABLE DEVELOPMENT OF TERRITORIES

open access: yesInterCarto. InterGIS, 2016
The study of problem associated with water availability and its mapping is due to the need to solve urgent water problems of the Russian regions for their sustainable development.
I. D. Rybkina   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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