Results 81 to 90 of about 2,486,223 (263)
Os efeitos da interação entre a forma do dossel vegetativo e os fatores ambientais locais resultam no microclima que determinará alterações em alguns aspectos fisiológicos da videira, podendo afetar significativamente o crescimento vegetativo, a ...
Paulo Márcio Norberto +3 more
doaj +1 more source
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Determination of the Water Potential Threshold at Which Rice Growth Is Impacted
Rice feeds 50% of the world’s population. Flooding is the most common irrigation system used for growing rice, a practice responsible for a large amount of water loss.
Caio Luiz dos Santos +3 more
doaj +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Em anos de baixa precipitação durante o período pós-semeadura, as plantas de capim-arroz tendem a emergir primeiro que as de arroz, promovendo maior competição inicial com a cultura.
G. Concenço, N.F. Lopes, A. Andres
doaj +1 more source
Sustainable Management of Alpine Water Potentials
Abstract : In Europe the need for high-quality freshwater has been increasing by a factor often since the beginning of the 20th century. Due to their geographic position and topographic feature the Alps are a major freshwater collector and hydrological storage system.
Meissner, Simon, Relier, Armin
openaire +2 more sources
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The study of problem associated with water availability and its mapping is due to the need to solve urgent water problems of the Russian regions for their sustainable development.
I. D. Rybkina +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source

