Results 81 to 90 of about 244,149 (269)
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
The effect of pumped-storage reservoir operation on biological productivity and water quality
, 1969 With the increased utilization of our water resources by a growing population, intelligent management of these resources, giving full consideration to all the relevant factors, becomes essential.
Neff, Stewart E., Simmons, George M. Jr.
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UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China
Advanced Science, EarlyView.This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang +3 more
wiley +1 more source
A productivity study of the Roanoke River above Niagra Dam in Virginia
, 1977 Deterioration of the water quality in the upper end of the Roanoke River of Smith Mountain Lake due to eutrophication has caused much concern. The Smith Mountain Lake impoundment was constructed in 1965 as a pump storage facility to generate electrical
Hoyle, Joyce L., Sherrard, Joseph H.
core
, 2023 Improving the accuracy of the green total factor productivity (GTFP) calculation has certain theoretical and practical value for sustainable development.
Cheng, Xuping Zhang · Xiang Chen · Ching‑Cheng Lu · Fu‑Yueh
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Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, EarlyView.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
Water productivity in agriculture: a review of empirical evidence for selected Asian countries and India [PDF]
In the context of the growing demand for water and the emerging water crisis, this paper examines the prospects for improving water use efficiency in agriculture that will help water savings and also increase crop yields per unit of water input ...
Ninan, K. N., Izumida, Y.
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Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng +11 more
wiley +1 more source