Results 81 to 90 of about 15,051,160 (301)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

State water quality management program, fiscal year 1974: pursuant to section 106, Federal water pollution control act amendments of 1972. DRAFT.

, 1973
28 pgs.Information regarding the State of Texas Water Quality Management Program fiscal year 1974. The Water Quality Management Program consists of a State strategy designed to meet the requirements of the Act.
Texas Water Quality Board.
core  

Water quality assessment of mardi river by using water quality index

Bibechana, 2013
The aimed study assesses the water quality of Mardi River applying National Sanitation Foundation (NSF) America developed index called Water Quality Index (WQI).
Shailendra Kumar Shah
doaj   +3 more sources

Complexation between copper(II)-dissolved organic matter shows heavy metal pollution in large-scale estuaries in the north-west Pacific

Communications Earth & Environment
Large-scale estuaries of Tumenjiang River, Liaohe River, Yellow River, Huaihe River, Changjiang River, and Zhujiang River in the north-west Pacific are confronted with latent heavy metal pollution.
Benxin Yu, Dongping Liu, Zhipeng Yao, Fang Yang, Hongjie Gao, Zhaoyong Bian   +5 more
doaj   +1 more source

Qualitative and quantitative analysis of selected brominated flame retardants in plastics of the building and construction sector

Emerging Contaminants
Brominated flame retardants (BFRs) have been used in plastics since the 1960s. Several are listed as persistent organic pollutants (POPs) under the Stockholm Convention due to their persistence, toxicity, bioaccumulation and/or mobility.
Fabian Mattersberger, Natsuko Kajiwara, Florian Part, Hidenori Matsukami, Roland Weber, Ronald A. Glabonjat, Erwin Rosenberg, Helmut Rechberger   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Environmental impact assessment, water quality analysis, Trinity River.

, 1976
236 p.A comprehensive water quality analysis and environmental impact assessment was undertaken at the Trinity River as part of a national assessment of anticipated environmental impact of theoretically achieving or not achieving the requirements and ...
National Commission on Water Quality.
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source