Results 41 to 50 of about 13,099,362 (290)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Multi-criteria potential groundwater contamination and human activities: Araras watershed, Brazil

RBRH, 2017
Assessment of groundwater contamination potential using geological, hydrological and hydrogeological attributes, is an efficient mechanism of sub-surface water resources protection and conservation.
Fabíola Geovanna Piga, Nícolas Guerra Rodrigues Tão, Mayara Herrmann Ruggiero, Darlan de Souza Marquezola, Welliton Leandro de Oliveira Boina, Carlos Wilmer Costa, José Augusto de Lollo, Reinaldo Lorandi, Edson Augusto Melanda, Luiz Eduardo Moschini   +9 more
doaj   +1 more source

A water quality assessment method based on an improved grey relational analysis and particle swarm optimization multi-classification support vector machine

Frontiers in Plant Science, 2023
Most of the water quality indicators that affect the results of river water quality assessment are gray and localized, thus the correlation between water quality indicators can be calculated using gray correlation analysis (GRA).However, GRA takes equal ...
Rongli Gai, Zhibin Guo
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Progress in the Research of the Toxicity Effect Mechanisms of Heavy Metals on Freshwater Organisms and Their Water Quality Criteria in China

Journal of Chemistry, 2020
Water quality criteria are the scientific basis for formulating water quality standards and environmental management practices. Due to the development of urbanization and industrialization, the problem of heavy metal pollution has become a serious ...
Ya-jun Hong, Wei Liao, Zhen-fei Yan, Ying-chen Bai, Cheng-lian Feng, Zu-xin Xu, Da-yong Xu   +6 more
doaj   +1 more source

Water Quality Sub Committee Report to the Planning Board of West Milford

, 2003
This report consists of an outline of the goals of West Milford's Water Quality Sub Committee in order to protect water resources. Some of the actions that the committee recommends involve wastewater treatment, storm water management, minimal ...

core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial patterns of hydroecological health in the semi-arid yellow river basin: Revelations from machine learning models

Ecological Indicators
The ecosystem of semi-arid watersheds is influenced by a combination of natural climate factors, rainfall, and habitat destruction, resulting in complex mechanisms of spatial differentiation and evolution of water ecological health.
Hao Liu, Rui Xia, Yan Chen, Ruining Jia, Ying Wei, Cao Yan, Lina Li, Kai Zhang, Yao Wang, Xiang Li   +9 more
doaj   +1 more source