Results 41 to 50 of about 12,667 (213)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Simulation and Application of Water Environment in Highly Urbanized Areas: A Case Study in Taihu Lake Basin

Hydrology
In the wake of frequent and intensive human activities, highly urbanized areas consistently grapple with severe water environmental challenges. It becomes imperative to establish corresponding water environment models for simulating and forecasting ...
Pengxuan Zhao, Chuanhai Wang, Jinning Wu, Gang Chen, Tianshu Zhang, Youlin Li, Pingnan Zhang   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Computer model improves real-time management of water quality

California Agriculture, 1997
Members of the San Joaquin River Management Program's Water Quality Subcommittee have developed a water-quality forecasting model to help improve the timing, coordination and management of agricultural drainage and reservoir releases into the San Joaquin
N Quinn, L Grober, J Kipps, C Chen, E Cummings   +4 more
doaj   +2 more sources

Integral water quality modelling of catchments

Water Science and Technology, 2001
ESWAT - Extended Soil and Water Assessment Tool - was developed to allow for an integral modelling of the water quantity and quality processes in river basins. The diffuse pollution sources are assessed by considering crop and soil processes and - together with the point sources - further transformed by an in-stream water quality module.
Van Griensven, Ann, Bauwens, Willy
openaire   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Modeling of Water Quality, Quantity, and Sustainability

Journal of Applied Mathematics, 2014
1 MOE Key Laboratory of Regional Energy Systems Optimization, S-C Resources and Environmental Research Academy, North China Electric Power University, Beijing 102206, China 2 Environmental Systems Engineering Program, Faculty of Engineering and Applied Science, University of Regina, Regina, SK, Canada S4S 0A2 3 State Key Laboratory of Hydro-Science and
Yongping Li, Guo H. Huang, Yuefei Huang, Xiao-Sheng Qin   +3 more
openaire   +5 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source